Pilot Study Comparing a New Skin Barrier Product to Petrolatum in Adults With Skin Barrier Problems

What this Trial Is About

Researchers are evaluating a new skin barrier product containing ceramide, virgin coconut oil, and cholesterol to treat adults with skin barrier dysfunction, including mild to moderate psoriasis, atopic dermatitis, contact dermatitis, seasonal xerosis, or clinically evident skin dryness. This pilot randomized controlled trial compares the new product to petrolatum, a standard treatment, to assess effects on skin hydration, sebum, redness, pigmentation, and symptoms like dryness and itch. Participants will apply either the novel barrier product or petrolatum twice daily on the right forearm for 28 days. They will receive supplies of the assigned product in identical containers to keep the study blinded. Follow-up visits occur weekly at weeks 1, 2, and 4, where researchers will measure skin condition and collect questionnaires. Participants will also keep a diary of product application. During each visit, non-invasive tests will measure skin hydration, sebum, redness, and pigmentation using specialized devices. Participants will rate their dryness and itch levels using a visual scale and complete satisfaction questionnaires. Researchers will monitor for any adverse skin reactions. The total participation lasts 28 days with assessments at multiple time points to evaluate safety and effectiveness.

Novel Skin Barrier Product Versus Petrolatum for Skin Barrier Dysfunction