Actively Recruiting
Novel Therapeutic Approach for Human T-cell Malignancies
Led by Istituto Oncologico Veneto IRCCS · Updated on 2025-12-08
120
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
Sponsors
I
Istituto Oncologico Veneto IRCCS
Lead Sponsor
I
Istituto Nazionale Tumori IRCSS-Fondazione G.Pascale
Collaborating Sponsor
AI-Summary
What this Trial Is About
This multicenter translational study, with prospective and retrospective samples, aims to identify new strategies to selectively eliminate neoplastic T cells by modulating intracellular ROS levels. Interactions between drugs capable of activating the apoptotic process (e.g., Venetoclax) and drugs capable of altering ROS homeostasis (e.g., inhibitors of the enzyme glucose-6-phosphate dehydrogenase) will be examined. The most promising compounds will be selected based on results obtained in vitro on cell lines and PDX already available in the laboratory, and then will be assayed ex vivo in cells obtained from patients with resistant/refractory T-cell neoplasms.
CONDITIONS
Official Title
Novel Therapeutic Approach for Human T-cell Malignancies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with pre- and post-thymic T-cell leukemia/lymphoma
- Patients of both sexes
- Age of patients older than 18 years
- Patient is willing to provide written and signed informed consent for participation in the study
You will not qualify if you...
- Serious illness or medical condition that does not allow the patient to be managed according to standard treatment protocols, including uncontrolled active infection.
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Istituto Nazionale Tumori Fondazione G.Pascale
Naples, Italy, 80100
Actively Recruiting
2
Istituto Oncologico Veneto
Padova, Italy, 35128
Actively Recruiting
Research Team
M
Michele Gottardi, MD
CONTACT
G
GianLuca De Salvo, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here