Actively Recruiting
Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia - ToolCAP
Led by University of Bern · Updated on 2025-06-18
3500
Participants Needed
9
Research Sites
86 weeks
Total Duration
On this page
Sponsors
U
University of Bern
Lead Sponsor
U
University of Witwatersrand, South Africa
Collaborating Sponsor
AI-Summary
What this Trial Is About
The ToolCAP study aims to see if using ultrasound to look at the lungs when children have symptoms of a lung infection will safely allow doctors to improve how they treat those infections. The study will also look at if it's possible to improve how doctors decide which children need antibiotics. * Lung infections are the most common reason for children to go to the clinic/hospital. * Doctors usually give an antibiotic to every child with a lung infection. * Lung infections can be caused by 2 different types of germs - bacteria or viruses. * Antibiotics only work against bacteria and not against viruses. Lung infections caused by viruses don't need antibiotics as the body fights them by itself. * Lots of research now shows that only 1 in 4 children with a lung infection actually needs an antibiotic, as the rest only have a viral infection causing the symptoms. * This means that 3 in 4 children get an antibiotic when they don't need it. * Taking too many antibiotics can cause problems for children as it can cause diseases like diabetes or asthma. * Nowadays, due to too many people using too many antibiotics, experts are starting to worry that bacteria are starting to become resistant (stronger than the antibiotic). * Ultrasound of the lungs appears to be a way of safely looking at the lungs to see if there is an infection and may help doctors better decide who needs an antibiotic. This study includes children aged 2 months-12 years who come to the hospital with a lung infection. Children who are very unwell or who have already had 2 days of antibiotic treatment will not be allowed to be in the study.
CONDITIONS
Official Title
Novel Tools to Improve Management of Paediatric Community-Acquired Pneumonia - ToolCAP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children aged 2 months to 12 years with cough or difficulty breathing
- Presence of fast breathing: >50 breaths/min (2-12 months), >40 breaths/min (1-<5 years), or >25 breaths/min (5-12 years)
- Presence of lower chest wall indrawing
You will not qualify if you...
- Repeat visit or follow-up for treated lower respiratory infection within 28 days
- Received antibiotic treatment for more than 48 hours at enrollment
- WHO IMCI danger signs: inability to drink/breastfeed, vomiting everything, convulsions with this illness, lethargy/unconscious
- Presence of jaundice
- Oxygen saturation (SpO2) <88%
- SpO2 <90% with severe respiratory distress or in children under 6 months
- Need for non-invasive ventilatory support
- Underlying diseases increasing risk of severe or unusual pneumonia
- HIV positive and either under 12 months old, requiring admission, or uncontrolled on treatment
- Caregiver unavailable or unwilling to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 9 locations
1
Université Cheikh Anta Diop
Dakar, Senegal, 10700
Actively Recruiting
2
Centre National Hospitalier d'Enfants Albert Royer
Dakar, Senegal, 25755
Actively Recruiting
3
Centre De Santé Gaspard Kamara
Dakar, Senegal, PG2RJH6
Actively Recruiting
4
Desmond Tutu TB Centre, Department of Paediatrics and Child Health, Stellenbosch University
Parow, Cape Town, South Africa
Actively Recruiting
5
University of Witwatersrand, MRC/Wits Rural Public Health and Health Transitions Research Unit
Parktown, Johannesburg, South Africa, 2193
Actively Recruiting
6
Tintswalo Hospital
Acornhoek, Mpumalanga, South Africa, 1375
Actively Recruiting
7
Themba Hospital
Mbombela, South Africa, 1245
Actively Recruiting
8
Ifakara Health Institute
Ifakara, Morogoro, Tanzania
Not Yet Recruiting
9
Muhimbili University of Health and Allied Sciences
Dar es Salaam, Tanzania
Actively Recruiting
Research Team
K
Kristina Keitel, MD, PhD
CONTACT
J
Jacques du Toit, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SUPPORTIVE_CARE
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here