Actively Recruiting
Assessment of Connective Tissue Graft vs. a New Collagen Matrix for Periodontal Tissue Thickening and Coverage of Single or Multiple Adjacent Gingival Recessions in Orthodontically Treated Patients
Led by University of Bern · Updated on 2026-02-27
60
Participants Needed
1
Research Sites
47 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Gingival recessions are a common issue affecting many adults worldwide and can lead to problems such as tooth sensitivity, root caries, and aesthetic concerns. This trial aims to compare a new volume stable collagen matrix to the standard connective tissue graft from the palate in treating gingival recessions, particularly in orthodontically treated patients. The study seeks to improve understanding of the best treatment methods for both upper and lower jaw recessions to enhance periodontal health and patient outcomes. Participants will be randomly assigned to one of two treatment groups. The test group will receive tissue thickening using the collagen matrix combined with a modified coronally advanced tunnel technique. The control group will undergo the standard treatment involving a connective tissue graft harvested from the palate with the same surgical technique. Both procedures aim to cover the gingival recession defect effectively. During the study, researchers will assess root coverage, early wound healing, tissue thickness increase, clinical attachment level, aesthetic scores, and patient satisfaction over a one-year period. Follow-up evaluations will include wound healing checks within the first week after surgery and assessments of periodontal tissue changes and patient-reported outcomes at one year. Participation includes regular visits and clinical measurements to monitor treatment effects and safety.
CONDITIONS
Brief Title
A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Written informed consent
- Healthy patients referred for recession coverage
- Miller Class I, II, or III facial gingival recession defect greater than 3 mm on the buccal side of the maxillary or mandibular canine and incisor area
You will not qualify if you...
- History of diseases causing low blood clotting
- Unstable diabetes mellitus
- Previous radiation treatment in the head and neck area
- Infectious diseases
- Heart diseases requiring preventive antibiotics before dental treatments
- Use of medications affecting the gums such as Ciclosporin A, Phenytoin, or calcium channel blockers
- Pregnant or breastfeeding patients
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 week
Participants receive either a connective tissue graft or a volume stable collagen matrix using a modified coronally advanced tunnel technique to cover gingival recession defects.
1 treatment visit and 1 follow-up visit within the first week
Duration - Up to 1 year
Participants are monitored for wound healing, tissue thickness increase, root coverage, clinical attachment, aesthetic outcomes, and patient satisfaction.
Visits at 2 days, 1 week, and periodic assessments up to 1 year
Trial Site Locations
Total: 1 location
1
Department of Periodontology
Bern, Switzerland, 3010
Actively Recruiting
Research Team
A
Anton Sculean, Prof
N
Nikolaos Pandis
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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