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Actively Recruiting

Phase Not Applicable
Age: 18Years +
All Genders
Healthy Volunteers
ID07437417

Comparison of Connective Tissue Graft and New Collagen Matrix for Treating Gingival Recession in Orthodontic Patients A Randomized Clinical Trial for Periodontal Tissue Thickening and Root Coverage

Led by University of Bern · Updated on 2026-02-27

60

Participants Needed

1

Research Sites

47 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

Gingival recessions are a common issue affecting many adults worldwide and can lead to problems such as tooth sensitivity, root caries, and aesthetic concerns. This trial aims to compare a new volume stable collagen matrix to the standard connective tissue graft from the palate in treating gingival recessions, particularly in orthodontically treated patients. The study seeks to improve understanding of the best treatment methods for both upper and lower jaw recessions to enhance periodontal health and patient outcomes. Participants will be randomly assigned to one of two treatment groups. The test group will receive tissue thickening using the collagen matrix combined with a modified coronally advanced tunnel technique. The control group will undergo the standard treatment involving a connective tissue graft harvested from the palate with the same surgical technique. Both procedures aim to cover the gingival recession defect effectively. During the study, researchers will assess root coverage, early wound healing, tissue thickness increase, clinical attachment level, aesthetic scores, and patient satisfaction over a one-year period. Follow-up evaluations will include wound healing checks within the first week after surgery and assessments of periodontal tissue changes and patient-reported outcomes at one year. Participation includes regular visits and clinical measurements to monitor treatment effects and safety.

CONDITIONS

Brief Title

A Novel Volume Stable Matrix for Gingival Recession Coverage at Teeth

Who Can Participate

Age: 18Years +
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Written informed consent
  • Healthy patients referred for recession coverage
  • Miller Class I, II, or III facial gingival recession defect greater than 3 mm on the buccal side of the maxillary or mandibular canine and incisor area
Not Eligible

You will not qualify if you...

  • History of diseases causing low blood clotting
  • Unstable diabetes mellitus
  • Previous radiation treatment in the head and neck area
  • Infectious diseases
  • Heart diseases requiring preventive antibiotics before dental treatments
  • Use of medications affecting the gums such as Ciclosporin A, Phenytoin, or calcium channel blockers
  • Pregnant or breastfeeding patients

Research Team

A

Anton Sculean, Prof

N

Nikolaos Pandis

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