Study of NOX4 and Mitochondria-Related Biomarkers in Early Autosomal Dominant Polycystic Kidney Disease for Patients Aged 15 to 40

What this Trial Is About

This research aims to evaluate NOX4 and related markers of mitochondrial injury and oxidative stress as real-time indicators of disease severity in patients with early autosomal dominant polycystic kidney disease ADPKD. The study focuses on young adults aged 15 to 40 years who have well-characterized early-stage ADPKD with preserved kidney function eGFR above 70 mLmin1.73m2. It includes patients with varying disease severity classified by ADPKD imaging criteria. The study is an observational, cross-sectional design including 60 patients categorized into five sub-classes Class 1A to 1E based on imaging classification. No treatments or interventions are administered rather, the focus is on collecting biological markers and imaging data at a single baseline time point. Participants will provide biological samples to measure NOX4 levels, mitochondrial DNA copy number, metabolites related to the tricarboxylic acid TCA cycle, and REDOX status. Kidney imaging will assess total kidney volume, and kidney function will be estimated through eGFR. These measurements will help determine the relationship between biomarkers and disease severity. The study duration is limited to baseline assessments without ongoing follow-up or treatment.

NOX4 and Related Biomarkers in ADPKD