Evaluating NT-II22 Salmon Collagen Supplement for Reducing Activity-Related Knee Discomfort and Improving Joint Function in Healthy Adults Aged 20 to 65

What this Trial Is About

Researchers are evaluating NT-II24, a natural marine supplement derived from salmon undenatured type II collagen, to see if it can reduce knee discomfort caused by physical activity in healthy adults aged 20 to 65. The study compares two doses of NT-II24 240 mg and 480 mg to a commonly used joint supplement containing glucosamine and chondroitin. The goal is to understand whether NT-II24 can improve knee comfort, movement, and quality of life better than this active comparator over a 12-week period. Participants are randomly assigned to one of three groups taking 240 mg of NT-II24 daily, 480 mg of NT-II24 daily, or glucosamine 1500 mg plus chondroitin 1300 mg daily. All supplements are taken orally once a day for 12 weeks. The study is conducted entirely remotely, with all materials like supplements, wearable fitness trackers, and blood sample kits sent by mail. No in-person visits are required, and participants use digital tools to report their knee discomfort, complete questionnaires, perform range of motion tests, and track physical activity. During the study, participants report knee pain weekly using a visual analog scale while doing a nominated activity that triggers discomfort, such as climbing stairs or squatting. They complete surveys on joint function, pain, and quality of life, and use a mobile app to measure knee movement. Wearable devices monitor daily activity levels, and blood samples taken at home assess inflammation markers. Researchers will analyze changes in knee discomfort, physical function, quality of life, heart rate variability, and psychological factors related to pain over the 12 weeks.

NT-II™ Collagen for Joint Discomfort and Function