Actively Recruiting
nTMS for Negative Symptom in Schizophrenia
Led by Central South University · Updated on 2025-12-05
40
Participants Needed
1
Research Sites
66 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to test the effectiveness of Navigated transcranial magnetic stimulation (nTMS) of left Supramarginal Gyrus for negative symptoms. In this double-blind, randomized controlled trial, patients will be assigned to active iTBS experimental group or sham iTBS group. Treatment will last for 10 days, and data will be collected at baseline, 1 day and 1 month after treatment.
CONDITIONS
Official Title
nTMS for Negative Symptom in Schizophrenia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of schizophrenia according to ICD-11
- Diagnosis confirmed with SCID-5-RV (DSM-5 Structured Clinical Interview)
- Score more than 4 points on any negative symptom item (N1-N7)
- Age less than 60 years
You will not qualify if you...
- Diagnosis of neurodevelopmental disorders, bipolar disorder, or substance use disorders (except alcohol and tobacco)
- Severe or acute physical illnesses such as traumatic brain injury, brain infections, cardiovascular or respiratory diseases, hematological disorders
- Genetic diseases like tuberous sclerosis, multiple sclerosis, Kleefstra syndrome, 22q11.2 deletion syndrome, Prader-Willi syndrome, Klinefelter syndrome
- Contraindications for MRI or rTMS including metal implants, epilepsy, cochlear implants
- Severe risk of self-injury or suicide
- Other conditions judged unsuitable for treatment by researchers
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Mental Health Institute of Second Xiangya Hospital,CSU
Changsha, Hunan, China, 410011
Actively Recruiting
Research Team
R
Renrong Wu, M.D., Ph.D.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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