Nutrition and Exercise Support to Reduce Obese Frailty in Men with Advanced Prostate Cancer on Androgen Deprivation Therapy

What this Trial Is About

Researchers are evaluating how personalized nutrition and exercise programs can help reduce obese frailty caused by androgen deprivation therapy ADT in prostate cancer survivors. The trial aims to study changes in body composition and myokine levels in the blood, as well as effects on muscle strength, respiratory muscle strength, functional capacity, inflammation, fatigue, diet, physical activity, and quality of life. The study also explores the relationship of these changes with prostate specific antigen PSA and testosterone levels, adherence to the interventions, and recruitment methods. Participants receive a customized diet plan for six months alongside a home-based exercise program that includes aerobic and resistance exercises performed 3 or more days per week for 10 to 30 minutes daily. Additionally, they follow a progressive resistance exercise routine targeting major muscle groups 5 days a week. Monthly educational meetings are held over the 6-month period to support and guide participants. During the study, participants are assessed for changes in body composition, muscle and respiratory strength, functional capacity, blood myokines and cytokines, dietary intake, physical activity, fatigue, and quality of life. These measures are taken from baseline through the 6-month intervention period. The trial monitors adherence to the nutrition and exercise plans and collects survey and quality-of-life data to evaluate the overall impact of the interventions on prostate cancer survivors receiving ADT.

Nutrition and Exercise Interventions for Androgen Deprivation Therapy-Induced Obese Frailty in Elderly and Non-Elderly Survivors of Advanced Prostate Cancer