Actively Recruiting
A Nutrition & Exercise Prehabilitation Intervention on Inflammatory Biomarkers in AI Cancer Patients
Led by University of Arizona · Updated on 2026-04-30
30
Participants Needed
1
Research Sites
137 weeks
Total Duration
On this page
Sponsors
U
University of Arizona
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to assess the feasibility of a prehab intervention among American Indian (AI) patients diagnosed with cancer and measure inflammatory biomarkers to evaluate the preliminary impact of the trial intervention. The central hypothesis is that this community-informed prehab intervention will demonstrate feasibility, patient acceptability, and modulation of host and tumor-microenvironment inflammatory biomarkers. Aim 1: Implement the prehab translational clinical trial for AI patients with cancer scheduled for treatment. Aim 2 Measure host and tumor-microenvironment (TME) biomarkers using paired serum and tissue samples to compare baseline and post-intervention levels of expression. Serum markers include CRP, IL-6, IL-10, TNFa, IGF-1, VEGF, complete blood count (CBC) with differential, comprehensive metabolic panel (CMP), and prealbumin. Tissue markers include Ki67, insulin receptor, TNFa, NFKB, NOS2, and cleaved caspase 3. Aim 3: (optional exploratory aim): Assess differential expression of inflammatory genes in the TME using tumor tissue samples to compare baseline and post-intervention levels of expression. This will be done with a panel that analyzes inflammatory genes only.
CONDITIONS
Official Title
A Nutrition & Exercise Prehabilitation Intervention on Inflammatory Biomarkers in AI Cancer Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18-80 years
- Diagnosed with cancer of any kind
- Scheduled at least 3 weeks out from first treatment
- Receiving care at San Carlos Apache Healthcare Corporation (SCAHC)
- Able to eat walnuts
- Able to do moderate-intensity exercise
You will not qualify if you...
- Digestive tract disease that would restrict diet modifications
- Allergy to the foods intended for the nutrition intervention
- Uncontrolled cardiac disease or other contraindications to moderate-intensity exercise
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Arizona Cancer Center
Tucson, Arizona, United States, 85724
Actively Recruiting
Research Team
J
Jennifer Erdrich, MD
CONTACT
M
Melissa Carton
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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