Actively Recruiting
OBESE-HFpEF: Towards Preventing Obesity Related HFpEF
Led by Zuyderland Medisch Centrum · Updated on 2026-04-20
250
Participants Needed
1
Research Sites
208 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Obesity, severe overweight, is a growing problem worldwide and increases the risk of heart failure, especially a type called heart failure with preserved ejection fraction (HFpEF). In HFpEF, the heart becomes stiffer. This makes it harder for the heart to fill with blood, which can lead to shortness of breath during physical activity. In the Netherlands, 15% of the population has obesity. In South Limburg, this is even higher at 19%. Among people with HFpEF, obesity is much more common: about 50% of these patients have obesity. Life expectancy in people with HFpEF is poor, and current treatment mainly focuses on reducing symptoms. Early recognition and treatment of risk factors, such as obesity, are therefore very important. This study includes about 250 people with obesity. Using a heart ultrasound and tests of blood and fat tissue, we will look for early signs of HFpEF and study the effects of weight loss. The measurements will be repeated after 1 and 2 years. The goal of this study is to better understand how obesity contributes to HFpEF and how weight loss affects the heart. This research may help improve future treatments for patients with HFpEF.
CONDITIONS
Official Title
OBESE-HFpEF: Towards Preventing Obesity Related HFpEF
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 235 years
- Eligible for surgical treatment for obesity according to Dutch guidelines: BMI 240 kg/m2 or BMI 235 kg/m2 with one or more obesity-related health conditions
You will not qualify if you...
- Unable to provide informed consent
- BMI greater than 60 kg/m2
- Unable to safely undergo metabolic bariatric surgery
- Unable to complete study measurements or tests
- Not proficient in Dutch language
- History of reduced left ventricular ejection fraction, severe heart valve defects, or severe congenital heart defects
- Previous metabolic bariatric surgery
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Zuyderland Medisch Centrum Heerlen
Heerlen, Limburg, Netherlands, 6419PC
Actively Recruiting
Research Team
L
Lukas Peeters, Master of Science in Medicine
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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