Tracking Brain Changes and Symptoms After Concussion Using Advanced MRI and Metabolomics in People Aged 9 to 50

What this Trial Is About

This research aims to better understand mild traumatic brain injury mTBI, often called concussion, which affects many people worldwide and can cause lasting symptoms like headaches, trouble concentrating, and light sensitivity. The study focuses on tracking how the brain changes over time after a concussion by comparing advanced MRI scans and symptom reports. It seeks to improve diagnosis and treatment by linking brain imaging and metabolite analysis with symptoms in youth and adult athletes. Participants will have three study visits within two weeks after a concussion, at three months, and at six months. During each visit, they will undergo 45-minute MRI sessions using multiple advanced techniques to assess brain structure and function. Urine and saliva samples will be collected for detailed metabolomic analysis. Participants will also complete questionnaires about their concussion symptoms and mental health. Throughout the study, researchers will track brain function and microstructure changes, along with self-reported symptoms to see how they evolve over time. This includes MRI measures like resting state brain activity and diffusion tensor imaging, plus metabolite levels in bodily fluids. The study aims to find out if brain abnormalities persist even after symptoms improve. Total participation lasts six months with regular follow-up assessments to monitor recovery and brain health.

Objective Concussion Assessment Using MRI and Metabolomics