Actively Recruiting
Use of Facial Feature to Objectively Diagnose and Monitor Treatment of Light Sensitivity
Led by Randy Kardon · Updated on 2025-11-24
120
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
This research aims to develop a new way to diagnose and monitor treatment for light sensitivity and headache by measuring facial features, pupil responses, retinal electrical signals, and nerve responses to light. The study includes people with conditions like traumatic brain injury (TBI) and migraine to better understand how light sensitivity occurs and how it can be managed. Participants will undergo several tests including videos of facial expressions, electrical recordings from facial muscles and the retina, and monitoring of heart rate and skin conductance using wristwatch devices. These tests use safe light stimuli, cameras, electrodes, and special imaging devices to gather objective data. The study includes groups such as healthy individuals, TBI patients with and without photosensitivity, and migraine patients with and without photosensitivity. During the study, participants will be evaluated with pupillography, ocular coherence tomography, videography, and electrophysiology tests. Researchers will measure how facial responses correlate with light sensitivity and compare biological markers between groups. Monitoring includes heart rate and skin conductance, and participants will report brightness and discomfort levels. The study lasts one day per participant, with assessments focused on understanding light sensitivity mechanisms and related changes in the eye and nervous system.
CONDITIONS
Brief Title
Objectively Diagnose and Monitor Treatment of Light Sensitivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Healthy individuals with a normal eye exam within the past year
- Age 18 to 80 years
- Traumatic Brain Injury (TBI) patients aged 18 to 80
- Patients with photosensitivity aged 18 to 80, including those with and without TBI
- Migraine patients with and without photosensitivity aged 18 to 80
You will not qualify if you...
- History of eye or systemic disorders affecting retina, optic nerve, visual pathway, or pupil (e.g., glaucoma, optic neuropathy, retinal disease, poorly controlled diabetes or hypertension)
- History of head trauma, concussion, or traumatic brain injury (for healthy controls and non-photosensitive groups)
- History of cervical or spinal injury or surgery
- Use of medications or eyedrops that affect pupil light reflex or muscle responses (e.g., topical autonomic drugs, ocular pharmacologic agents, sedatives like benzodiazepines or barbiturates, opioid narcotics)
- Being light sensitive or having migraine headaches (for healthy control subjects and TBI patients without photosensitivity)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - 1 day
Participants undergo a series of objective measurements including pupillography, retinal imaging with ocular coherence tomography, facial videography, electrophysiology, and continuous monitoring of heart rate and skin conductance using wrist-watch sensor devices to diagnose and monitor treatment of light sensitivity.
1 visit (in-person)
Trial Site Locations
Total: 1 location
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
J
Julie Nellis, BSN
J
Jan Full, BSN
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
5
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