Objective Diagnosis and Monitoring of Light Sensitivity Using Facial and Eye Measurements in Adults Aged 18 to 80

What this Trial Is About

This research aims to develop a new way to diagnose and monitor treatment for light sensitivity and headache by measuring facial features, pupil responses, retinal electrical signals, and nerve responses to light. The study includes people with conditions like traumatic brain injury TBI and migraine to better understand how light sensitivity occurs and how it can be managed. Participants will undergo several tests including videos of facial expressions, electrical recordings from facial muscles and the retina, and monitoring of heart rate and skin conductance using wristwatch devices. These tests use safe light stimuli, cameras, electrodes, and special imaging devices to gather objective data. The study includes groups such as healthy individuals, TBI patients with and without photosensitivity, and migraine patients with and without photosensitivity. During the study, participants will be evaluated with pupillography, ocular coherence tomography, videography, and electrophysiology tests. Researchers will measure how facial responses correlate with light sensitivity and compare biological markers between groups. Monitoring includes heart rate and skin conductance, and participants will report brightness and discomfort levels. The study lasts one day per participant, with assessments focused on understanding light sensitivity mechanisms and related changes in the eye and nervous system.

Objectively Diagnose and Monitor Treatment of Light Sensitivity