Actively Recruiting
Objectively Diagnose and Monitor Treatment of Light Sensitivity
Led by Randy Kardon · Updated on 2025-11-24
120
Participants Needed
1
Research Sites
442 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and autonomic nerve responses to light.
CONDITIONS
Official Title
Objectively Diagnose and Monitor Treatment of Light Sensitivity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 80 years
- Healthy individuals with a normal eye exam within the past year (for healthy control group)
- Traumatic Brain Injury (TBI) patients aged 18 to 80 without photosensitivity or headache
- Patients aged 18 to 80 with photosensitivity symptoms, with or without an identified cause
- Patients aged 18 to 80 with photosensitivity related to post-traumatic brain injury
You will not qualify if you...
- History of eye or systemic disorders affecting the retina, optic nerve, visual pathway, or pupil, including glaucoma, optic neuropathy, retinal disease, or uncontrolled diabetes and/or hypertension
- History of head trauma, concussion, traumatic brain injury (for certain groups), or cervical/spinal injury or surgery
- Use of medications or eyedrops that affect pupil light reflex or electromyogram, including topical autonomic drugs, ocular pharmacologic agents, sedatives (e.g., benzodiazepines or barbiturates), or opioid narcotics
- Being light sensitive or experiencing migraine headaches (for healthy control and certain TBI groups)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Iowa Health Care
Iowa City, Iowa, United States, 52242
Actively Recruiting
Research Team
J
Julie Nellis, BSN
CONTACT
J
Jan Full, BSN
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
5
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