Actively Recruiting
Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.
Led by The First Affiliated Hospital of Zhengzhou University · Updated on 2025-09-12
15000
Participants Needed
162
Research Sites
447 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.
CONDITIONS
Official Title
Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Chronic hepatitis B infection (HBsAg-positive for 6 months or longer)
- Age 18 years or older
- Currently receiving or planned treatment with entecavir (ETV), tenofovir disoproxil fumarate (TDF), tenofovir alafenamide fumarate (TAF), tenofovir amibufenamide (TMF), or Peginterferon α-2b injection
- Patients who are pegylated interferon α-2b-naïve or re-initiating pegylated interferon α-2b therapy
- Provided written informed consent to participate
You will not qualify if you...
- Severe liver dysfunction or decompensated cirrhosis
- Participation in any other clinical trials
- Diagnosis of hepatocellular carcinoma (HCC)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 162 locations
1
Huaxian People's Hospital
Anyang, China
Actively Recruiting
2
Linzhou City People's Hospital
Anyang, China
Actively Recruiting
3
Neihuang County People's Hospital
Anyang, China
Actively Recruiting
4
Tangyin County People's Hospital
Anyang, China
Actively Recruiting
5
The Fifth People's Hospital of Anyang
Anyang, China
Actively Recruiting
6
The First Affiliated Hospital of Xinxiang Medical University (Hua County Branch)
Anyang, China
Actively Recruiting
7
Guangzhou First People's Hospital
Guangzhou, China
Actively Recruiting
8
The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital)
Guangzhou, China
Actively Recruiting
9
Hebi Coal Mining Group General Hospital
Hebi, China
Actively Recruiting
10
Hebi Infectious Disease Hospital
Hebi, China
Actively Recruiting
11
Junxian County People's Hospital
Hebi, China
Actively Recruiting
12
Bo'ai County People's Hospital
Jiaozuo, China
Actively Recruiting
13
Mengzhou Hospital of Traditional Chinese Medicine
Jiaozuo, China
Actively Recruiting
14
Qinyang People's Hospital
Jiaozuo, China
Actively Recruiting
15
The Secend People's Hospital of Jiaozuo
Jiaozuo, China
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16
The Third People's Hospital of Jiaozuo
Jiaozuo, China
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17
Xiuwu People's Hospital
Jiaozuo, China
Actively Recruiting
18
Wenxian People's Hospital
Jiayuguan, China
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19
Jiyang County Hospital of Traditional Chinese Medicine
Jinan, China
Actively Recruiting
20
Shandong Public Health Clinical Center
Jinan, China
Actively Recruiting
21
Jiyuan People's Hospital
Jiyuan, China
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22
Jiyuan Traditional Chinese Medicine Hospital
Jiyuan, China
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23
Huaihe Hospital of Henan University
Kaifeng, China
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24
Infectious Diseases Hospital of Kaifeng
Kaifeng, China
Actively Recruiting
25
Kaifeng Central Hospital
Kaifeng, China
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26
Kaifeng Hospital of Traditional Chinese Medicine
Kaifeng, China
Actively Recruiting
27
Lankao First Hospital Group
Kaifeng, China
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28
Qixian People's Hospital
Kaifeng, China
Actively Recruiting
29
The People's Hospital of Weishi
Kaifeng, China
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30
Tongxu County People's Hospital
Kaifeng, China
Actively Recruiting
31
Weishi County People's Hospital
Kaifeng, China
Actively Recruiting
32
Linyi Hospital of Traditional Chinese Medicine
Linyi, China
Actively Recruiting
33
Linyi People's Hospital
Linyi, China
Actively Recruiting
34
Linying County People's Hospital
Luohe, China
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35
Luohe Central Hospital
Luohe, China
Actively Recruiting
36
Luanchuan County People's Hospital
Luoyang, China
Actively Recruiting
37
Luoning County People's Hospital
Luoyang, China
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38
Luoyang Central Hospital
Luoyang, China
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39
Luoyang First People's Hospital
Luoyang, China
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40
Luoyang Third People's Hospital
Luoyang, China
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41
Ruyang County People's Hospital
Luoyang, China
Actively Recruiting
42
The First Affiliated Hospital of Henan University of Science and Technology
Luoyang, China
Actively Recruiting
43
Xin'an County People's Hospital
Luoyang, China
Actively Recruiting
44
Yichuan County Hospital of Traditional Chinese Medicine
Luoyang, China
Actively Recruiting
45
Yiyang County People's Hospital
Luoyang, China
Actively Recruiting
46
Dengzhou Central Hospital
Nanyang, China
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47
Dengzhou People's Hospital
Nanyang, China
Actively Recruiting
48
Fangcheng County People's Hospital
Nanyang, China
Actively Recruiting
49
Nanyang Central Hospital
Nanyang, China
Actively Recruiting
50
Nanyang First People's Hospital
Nanyang, China
Actively Recruiting
51
Nanyang Oilfield General Hospital
Nanyang, China
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52
Nanyang Second General Hospital
Nanyang, China
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53
Nanzhao County People's Hospital
Nanyang, China
Actively Recruiting
54
Neixiang County People's Hospital
Nanyang, China
Actively Recruiting
55
Sheqi County People's Hospital
Nanyang, China
Actively Recruiting
56
Tanghe County People's Hospital
Nanyang, China
Actively Recruiting
57
The First Affiliated Hospital of Nanyang Medical College
Nanyang, China
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58
Xinye County People's Hospital
Nanyang, China
Actively Recruiting
59
Xixia County People's Hospital
Nanyang, China
Actively Recruiting
60
Zhenping People's Hospital
Nanyang, China
Actively Recruiting
61
Ningbo Medical Center Iihuili hospital
Ningbo, China
Actively Recruiting
62
General Hospital Of Pingmei Shenma Group
Pingdingshan, China
Actively Recruiting
63
Lushan County People's Hospital
Pingdingshan, China
Actively Recruiting
64
People's Hospital of Baofeng
Pingdingshan, China
Actively Recruiting
65
Pingdingshan First People's Hospital
Pingdingshan, China
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66
Ruzhou First People's Hospital
Pingdingshan, China
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67
Ye County People's Hospital
Pingdingshan, China
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68
Pingdu Municipal People's Hospital
Pingdu, China
Actively Recruiting
69
Anyang District Hospital
Pujiang, China
Actively Recruiting
70
Chinese Medicine Hospital of puyang
Pujiang, China
Actively Recruiting
71
Fanxian People's Hospital
Pujiang, China
Actively Recruiting
72
Nanle County People's Hospital
Pujiang, China
Actively Recruiting
73
Puyang People's Hospital
Pujiang, China
Actively Recruiting
74
The Fifth People's Hospital of Puyang City
Pujiang, China
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75
People's Hospital of Rizhao
Rizhao, China
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76
Huanghe Sanmenxia Hospital
Sanmenxia, China
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77
Sanmenxia Central Hospital
Sanmenxia, China
Actively Recruiting
78
The First People's Hospital of Lingbao
Sanmenxia, China
Actively Recruiting
79
The Sixth People's Hospital of Lingbao
Sanmenxia, China
Actively Recruiting
80
Yimei Group General Hospital
Sanmenxia, China
Actively Recruiting
81
Minquan County Hospital of Traditional Chinese Medicine
Shangqiu, China
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82
Minquan County People's Hospital
Shangqiu, China
Actively Recruiting
83
Second People's Hospital Xiayi Country
Shangqiu, China
Actively Recruiting
84
Shangqiu Fourth People's Hospital
Shangqiu, China
Actively Recruiting
85
Shangqiu Hospital of Traditional Chinese Medicine
Shangqiu, China
Actively Recruiting
86
Shangqiu Municipal Hospital
Shangqiu, China
Actively Recruiting
87
Shangqiu Third People's Hospital
Shangqiu, China
Actively Recruiting
88
Sui County People's Hospital
Shangqiu, China
Actively Recruiting
89
Suixian County Hospital of Traditional Chinese Medicine
Shangqiu, China
Actively Recruiting
90
The First People's Hospital of Shangqiu
Shangqiu, China
Actively Recruiting
91
The People's Hospital of Yucheng County
Shangqiu, China
Actively Recruiting
92
Xiayi County People's Hospital
Shangqiu, China
Actively Recruiting
93
Yongcheng Central Hospital
Shangqiu, China
Actively Recruiting
94
Yucheng County People's Hospital
Shangqiu, China
Actively Recruiting
95
Zhecheng People's Hospital
Shangqiu, China
Actively Recruiting
96
Zhecheng Traditional Chinese Medicine Hospital Co., Ltd.
Shangqiu, China
Actively Recruiting
97
Changyuan County People's Hospital
Xinxiang, China
Actively Recruiting
98
Huixian People's Hospital
Xinxiang, China
Actively Recruiting
99
The First Affiliated Hospital of Xinxiang Medical University
Xinxiang, China
Actively Recruiting
100
The Third Affiliated Hospital of Xinxiang Medical University
Xinxiang, China
Actively Recruiting
101
Xinxiang First People's Hospital
Xinxiang, China
Actively Recruiting
102
Xinxiang Infectious Disease Hospital
Xinxiang, China
Actively Recruiting
103
Yanjin County People's Hospital
Xinxiang, China
Actively Recruiting
104
Guangshan County People's Hospital
Xinyang, China
Actively Recruiting
105
Gushi County People's Hospital
Xinyang, China
Actively Recruiting
106
Huaibin County People's Hospital
Xinyang, China
Actively Recruiting
107
Huangchuan County People's Hospital
Xinyang, China
Actively Recruiting
108
Luoshan County People's Hospital
Xinyang, China
Actively Recruiting
109
Xinyang Central Hospital
Xinyang, China
Actively Recruiting
110
Xinyang Specialized Hospital for Infectious Diseases
Xinyang, China
Actively Recruiting
111
Xixian People's Hospital
Xinyang, China
Actively Recruiting
112
Changge People's Hospital
Xuchang, China
Actively Recruiting
113
Xiangcheng County Traditional Chinese Medicine Hospital
Xuchang, China
Actively Recruiting
114
Xiangcheng People's Hospital
Xuchang, China
Actively Recruiting
115
Xuchang Central Hospital
Xuchang, China
Actively Recruiting
116
Xuchang People's Hospital
Xuchang, China
Actively Recruiting
117
Yanling County People's Hospital
Xuchang, China
Actively Recruiting
118
Yanling County Traditional Chinese Medicine Hospital
Xuchang, China
Actively Recruiting
119
Yuzhou Central Hospital
Xuchang, China
Actively Recruiting
120
Yuzhou City People's Hospital
Xuchang, China
Actively Recruiting
121
Chinese People's Liberation Army Joint Logistics Support Force 970 Hospital,
Yantai, China
Actively Recruiting
122
Jiaozuo People's Hospital
Yantai, China
Actively Recruiting
123
Yantai Qishan Hospital
Yantai, China
Actively Recruiting
124
Gongyi City People's Hospital
Zhengzhou, China
Actively Recruiting
125
The First Affiliated Hospital of Henan University of Chinese Medicine
Zhengzhou, China
Actively Recruiting
126
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Actively Recruiting
127
The First People's Hospit of Zhengzhou
Zhengzhou, China
Actively Recruiting
128
The Second Affiliated Hospital of Zhengzhou University
Zhengzhou, China
Actively Recruiting
129
The Six People's Hospit of Zhengzhou
Zhengzhou, China
Actively Recruiting
130
The Third People's Hospit of Zhengzhou
Zhengzhou, China
Actively Recruiting
131
Third Affiliated Hospital of Henan University of Traditional Chinese Medicine
Zhengzhou, China
Actively Recruiting
132
Xingyang People's Hospital
Zhengzhou, China
Actively Recruiting
133
Zhengzhou Central Hospital
Zhengzhou, China
Actively Recruiting
134
Zhengzhou Traditional Chinese Medicine Hospital
Zhengzhou, China
Actively Recruiting
135
Zhongmu County Hospital of Traditional Chinese Medicine
Zhengzhou, China
Actively Recruiting
136
Zhongmu County People's Hospital
Zhengzhou, China
Actively Recruiting
137
Zhongshan Second People's Hospital
Zhongshan, China
Actively Recruiting
138
Dancheng County People's Hospital
Zhoukou, China
Actively Recruiting
139
Fugou County People's Hospital
Zhoukou, China
Actively Recruiting
140
Shenqiu People's Hospital
Zhoukou, China
Actively Recruiting
141
Taikang County People's Hospital
Zhoukou, China
Actively Recruiting
142
The Frist People's Hospital Of Xiangcheng
Zhoukou, China
Actively Recruiting
143
The People's Hospital Of Luyi
Zhoukou, China
Actively Recruiting
144
Xihua County Hospital of Traditional Chinese Medicine
Zhoukou, China
Actively Recruiting
145
Xihua County People's Hospital
Zhoukou, China
Actively Recruiting
146
Zhoukou Central Hospital
Zhoukou, China
Actively Recruiting
147
Zhoukou Hospital Of TCM
Zhoukou, China
Actively Recruiting
148
Zhoukou Specialized Disease Hospital
Zhoukou, China
Actively Recruiting
149
People's Hospital of Queshan
Zhumadian, China
Actively Recruiting
150
Pingyu County People's Hospital
Zhumadian, China
Actively Recruiting
151
Runan County Hospital of Traditional Chinese Medicine
Zhumadian, China
Actively Recruiting
152
Shangcai County People's Hospital
Zhumadian, China
Actively Recruiting
153
The 990th Hospital of the Joint Logistics Support Force of the PLA
Zhumadian, China
Actively Recruiting
154
The People's Hospital Of Biyang Country
Zhumadian, China
Actively Recruiting
155
Xincai County People's Hospital
Zhumadian, China
Actively Recruiting
156
Xincai Medical University
Zhumadian, China
Actively Recruiting
157
Xiping County People's Hospital
Zhumadian, China
Actively Recruiting
158
Zhengyang County People's Hospital
Zhumadian, China
Actively Recruiting
159
Zhumadian Central Hospital
Zhumadian, China
Actively Recruiting
160
Zhumadian Traditional Chinese Medicine Hospital
Zhumadian, China
Actively Recruiting
161
Zibo Central Hospital
Zibo, China
Actively Recruiting
162
Zibo Infectious Diseases Hospital (Zibo Fourth People's Hospital)
Zibo, China
Actively Recruiting
Research Team
H
Hongxia Liang
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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