Observational Study of First-Time Ischemic Stroke or TIA in Adults Aged 18 to 50 Investigating Blood Clotting, Inflammation, and Vessel Health

What this Trial Is About

Researchers are studying the causes and outcomes of ischemic stroke or transient ischemic attack TIA in young adults aged 18 to 50 years. This observational study aims to understand how blood clotting, inflammation, and damage to blood vessel linings contribute to stroke in this age group. The study also explores how these factors affect the risk of stroke recurrence and bleeding complications over time. The study includes two groups patients aged 18 to 50 who have had a first-ever ischemic stroke or TIA, and healthy controls of the same age range without cardiovascular disease. Researchers will collect blood samples at the start and after three months to analyze clotting and inflammation markers. Participants will also undergo 3 Tesla MRI scans to assess blood vessel walls and complete questionnaires about possible stroke triggers. Participants will be involved in evaluations at baseline and three months, including blood tests for coagulation and inflammation, MRI scans, and questionnaires. Researchers will track participants for up to 10 years to monitor recurrent cardiovascular events, venous thrombosis, malignancy, bleeding complications, and overall survival. The study will compare findings between stroke patients and healthy controls to better understand stroke mechanisms in young adults.

Observational Dutch Young Symptomatic StrokE studY - nEXT