Prospective Observational Study of Confirmed Mpox Infection in Adults in Brazil

What this Trial Is About

This research aims to evaluate clinical and immune-metabolic factors that may influence the risk, severity, and outcomes such as hospitalization or death in patients infected with the Mpox virus in Brazil. The study focuses on people diagnosed with monkeypox and observes how their condition progresses over time. Participants are people with laboratory-confirmed Mpox infection, identified by tests like PCR, culture, or antigen tests on samples from blood, throat, anal, or skin lesions taken within five days of joining the study. The study is observational, meaning it collects data without assigning treatments, and follows patients for 90 days after inclusion through decentralized visits. During the study, researchers will monitor symptoms such as rash, fever, pain, chills, weakness, hospitalizations, and neurological effects. They will also perform laboratory tests including viral genomic analysis and metabolomics on blood and skin samples at various times. Follow-up occurs at days 15, 30, 60, and 90, with monitoring for death and hospitalizations, helping to understand the course of Mpox infection over this period.

Observational, Prospective, Cohort Study of Mpox Infection in Brazil (NETPOX)