Actively Recruiting
Observational, Prospective, Multi-centric Study Exploring HER2 Mutations Incidence and Therapeutic Management in aNSCLC
Led by Gruppo Oncologico Italiano di Ricerca Clinica · Updated on 2026-03-05
50
Participants Needed
22
Research Sites
76 weeks
Total Duration
On this page
Sponsors
G
Gruppo Oncologico Italiano di Ricerca Clinica
Lead Sponsor
A
AstraZeneca
Collaborating Sponsor
AI-Summary
What this Trial Is About
The HEROS study is an Italian observational multicenter prospective study aimed to investigate the current diagnostic and therapeutical approach towards HER2 mutated NSCLC in clinical practice. The enrolment will start in September 2024 until September 2025. A 12-months follow-up window will be performed.
CONDITIONS
Official Title
Observational, Prospective, Multi-centric Study Exploring HER2 Mutations Incidence and Therapeutic Management in aNSCLC
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female, aged at least 18 years
- Pathologically confirmed diagnosis of NSCLC from September 2024 to September 2025
- Locally advanced (stage IIIC), not amenable to multimodal approach (chemo-radiotherapy), or metastatic (stage IV) NSCLC according to TNM VIII edition
- Enrolled in ATLAS project
- Presence of HER2 mutation (for Cohort 2)
- Availability of tissue sample from the first 50 patients enrolled in Cohort 2 (for Cohort 3)
- Written informed consent (HEROS project) must be obtained before any study-related procedure
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
IRCCS "Giovanni Paolo II"
Bari, BA, Italy, 70124
Active, Not Recruiting
2
Istituto Romagnolo per lo Studio dei Tumori IRST "Dino Amadori"
Meldola, FC, Italy, 47014
Not Yet Recruiting
3
Arcispedale Sant'Anna
Ferrara, FE, Italy, 44124
Not Yet Recruiting
4
Ospedale Policlinico San Martino
Genova, GE, Italy, 16132
Not Yet Recruiting
5
Ospedale Versilia
Lido di Camaiore, LU, Italy, 55041
Active, Not Recruiting
6
Azienda Sanitaria Toscana Nord - Ovest
Lucca, LU, Italy, 55100
Active, Not Recruiting
7
IRCCS San Gerardo dei Tintori
Monza, MB, Italy, 20900
Not Yet Recruiting
8
IRCCS Ospedale San Raffaele
Milan, MI, Italy, 20132
Not Yet Recruiting
9
ASST Grande Ospedale Metropolitano Niguarda
Milan, MI, Italy, 20162
Not Yet Recruiting
10
Istituto Clinico Humanitas IRRCS
Rozzano, MI, Italy, 20089
Not Yet Recruiting
11
Azienda Ospedaliero - Universitaria di Modena
Modena, MO, Italy, 41125
Active, Not Recruiting
12
Istituto Oncologico Veneto IRCCS
Padova, PD, Italy, 35128
Actively Recruiting
13
Azienda Ospedaliera di Perugia
Perugia, PG, Italy, 06129
Active, Not Recruiting
14
Centro di Riferimento Oncologico IRCCS di Aviano
Aviano, PN, Italy, 33081
Not Yet Recruiting
15
Azienda Ospedaliera - Universitaria di Parma
Parma, PR, Italy, 43126
Actively Recruiting
16
Fondazione IRCCS Policlinico S. Matteo
Pavia, PV, Italy, 27100
Not Yet Recruiting
17
Azienda Ospedaliero - Universitaria di Reggio Emilia
Reggio Emilia, RE, Italy, 42122
Active, Not Recruiting
18
Istituto Nazionale dei Tumori Regina Elena IRCCS - IFO
Roma, RM, Italy, 00144
Not Yet Recruiting
19
Azienda Ospedaliera San Camillo Forlanini
Roma, RM, Italy, 00152
Active, Not Recruiting
20
AOU San Luigi Orbassano
Orbassano, TO, Italy, 10043
Not Yet Recruiting
21
Azienda Sanitaria Universitaria Friuli Centrale (ASU FC)
Udine, UD, Italy, 33100
Not Yet Recruiting
22
Azienda Ospedaliera Universitaria Integrata Verona
Verona, VR, Italy, 37126
Not Yet Recruiting
Research Team
M
Marcello Tiseo, MD, PhD
CONTACT
A
Alessandro Leonetti, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here