Actively Recruiting
Observational RegIstry of Effectiveness and Safety of teNecTeplase in reAl worLd Settings in China
Led by Beijing Tiantan Hospital · Updated on 2026-01-06
10000
Participants Needed
1
Research Sites
186 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The ORIENTAL study is a prospective, multicenter, continuously enrolled real-world cohort designed to evaluate the effectiveness and safety of intravenous tenecteplase for acute ischemic stroke (AIS) in routine clinical practice across China. Approximately 10,000 patients from about 200 hospitals will be included. Eligible adults with imaging-confirmed AIS who receive tenecteplase as part of standard care will be consecutively enrolled and followed through 90 days. The study will describe patient characteristics, treatment processes, functional outcomes, and safety events, and will also explore inter-hospital variability and subgroup differences to support quality improvement and guide nationwide implementation of tenecteplase therapy.
CONDITIONS
Official Title
Observational RegIstry of Effectiveness and Safety of teNecTeplase in reAl worLd Settings in China
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 years or older
- Diagnosed with acute ischemic stroke confirmed by imaging (CT or MRI)
- Treated with intravenous tenecteplase at the participating institution
- Provided written informed consent, signed by the patient or their legally authorized representative
- Capable of completing follow-up assessments
You will not qualify if you...
- Received reperfusion therapy prior to hospital admission (e.g., intravenous thrombolysis before admission)
- Participating in any clinical trials where the intervention may affect this study's outcomes
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Beijing Tiantan Hospital, Capital Medical University
Beijing, China, 100070
Actively Recruiting
Research Team
Y
Yongjun Wang, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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