Actively Recruiting
Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United Kingdom
Led by AstraZeneca · Updated on 2026-04-23
350
Participants Needed
29
Research Sites
232 weeks
Total Duration
On this page
Sponsors
A
AstraZeneca
Lead Sponsor
U
UKCLL Forum
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a retrospective observational research study to describe the characteristics and real-world clinical outcomes of patients with chronic lymphocytic leukaemia receiving acalabrutinib in the United Kingdom (the EPIC study). Physicians treating chronic lymphocytic leukaemia patients with acalabrutinib, where the patients started treatment as part of the acalabrutinib Early Access Programme (EAP), will be invited to recruit patients. Clinical data will be extracted from the patients' clinical records in line with local laws. Data from this study will provide UK-specific real-world data on patients who were started on acalabrutinib as part of the UK acalabrutinib EAP.
CONDITIONS
Official Title
Observational Study of Acalabrutinib in Patients With Chronic Lymphocytic Leukaemia in the United Kingdom
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Treatment-na�efve patients with chronic lymphocytic leukaemia (CLL) who started acalabrutinib as part of the UK Early Access Programme
- Received their first dose of acalabrutinib between April 1, 2020, and April 1, 2021
- Patients aged 18 years or older
- Patients later found to have small lymphocytic lymphoma (SLL) may also be included
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Trial Site Locations
Total: 29 locations
1
Research Site
Aylesbury, United Kingdom
Actively Recruiting
2
Research Site
Bath, United Kingdom
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3
Research Site
Birmingham, United Kingdom
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4
Research Site
Bournemouth, United Kingdom
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5
Research Site
Cardiff, United Kingdom
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6
Research Site
Cornwall, United Kingdom
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7
Research Site
Dartford, United Kingdom
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8
Research Site
Derby, United Kingdom
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9
Research Site
Doncaster, United Kingdom
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10
Research Site
Dorset, United Kingdom
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11
Research Site
Eastbourne, United Kingdom
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12
Research Site
Hull, United Kingdom
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13
Research Site
Leicester, United Kingdom
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14
Research Site
Lincoln, United Kingdom
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15
Research Site
Liverpool, United Kingdom
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16
Research Site
London, United Kingdom, SE1 9RT
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17
Research Site
London, United Kingdom, W12 OHS
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18
Research Site
Mid Yorkshire, United Kingdom
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19
Research Site
Middlesbrough, United Kingdom
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20
Research Site
Newcastle, United Kingdom
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21
Research Site
North Shields, United Kingdom
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22
Research Site
Norwich, United Kingdom
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23
Research Site
Nottingham, United Kingdom
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24
Research Site
Oxford, United Kingdom
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25
Research Site
Plymouth, United Kingdom
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26
Research Site
Southampton, United Kingdom
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27
Research Site
Stockton-on-Tees, United Kingdom
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28
Research Site
Stoke-on-Trent, United Kingdom
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29
Research Site
Wigan, United Kingdom
Actively Recruiting
Research Team
A
AstraZeneca Clinical Study Information Center
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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