Actively Recruiting
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Diagnosed According to cIMPACT-NOW Recommendations and the 2021 WHO Classification
Led by European Organisation for Research and Treatment of Cancer - EORTC · Updated on 2025-12-17
1650
Participants Needed
42
Research Sites
552 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the impact of the new 2021 WHO classification, based on cIMPACT-NOW recommendations, on grouping patients with primary brain tumors. This study aims to determine if the new classification creates more consistent patient groups than the previous 2016 system and to develop provisional treatment guidelines based on the experiences of EORTC investigators. The study focuses on various newly defined tumor entities and how current treatments may work for these groups. This is an observational study with no interventions or treatments assigned by the study team. It includes multiple cohorts of patients with different types of primary brain tumors such as gliomas, embryonal tumors, meningiomas, and others. The study collects clinical data, imaging, and tissue samples to analyze patient characteristics, treatments, and outcomes according to both the 2016 and 2021 WHO classifications. Participants will be followed for up to 10 years, with data collected at enrollment and every six months during follow-up. Assessments include tumor responses, progression-free survival, overall survival, patient and disease characteristics, and neuroimaging features at diagnosis and progression. The study also aims to generate reference datasets to support future clinical trials. There is no treatment involved, and patient monitoring focuses on collecting information to better understand brain tumor classification and outcomes.
CONDITIONS
Brief Title
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Newly diagnosed or recurrent primary brain tumors within one of the 17 cohorts of interest
- Archival tumor tissue from primary tumor available at the site (tissue from first surgery preferred, but tissue from recurrence surgery allowed except for Cohort 16 where only tissue from first surgery is allowed)
- Available MRI or CT scans from primary brain tumor at initial diagnosis
- Patient's consent provided
- For deceased patients, data or biological material can be used if prior consent was given, a relative consents, or a legal declaration applies
- No documented objection by patient to reuse of data, biological material, or imaging for research
- Notification to an ethics committee for reuse of these data and compliance with national requirements
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 10 years
Participants who undergo routine care are observed to collect data on tumor characteristics, treatments, and outcomes according to the 2021 WHO classification.
Assessments at enrolment and every 6 months during follow-up
Trial Site Locations
Total: 42 locations
1
Innsbruck Universitaetsklinik
Innsbruck, Austria
Actively Recruiting
2
Universitaetsklinikum Wien - AKH unikliniken
Vienna, Austria
Actively Recruiting
3
Onze Lieve Vrouw Ziekenhuis
Aalst, Belgium
Actively Recruiting
4
Institut Jules Bordet
Anderlecht, Belgium
Actively Recruiting
5
Universitair Ziekenhuis Brussel
Brussels, Belgium
Actively Recruiting
6
C.H.U. Sart-Tilman
Liège, Belgium
Actively Recruiting
7
AZ Delta - Campus Rumbeke
Roeselare, Belgium
Actively Recruiting
8
CHU Lyon - Hopital neurologique Pierre Wertheimer
Lyon, France
Actively Recruiting
9
Hopital de La Timone
Marseille, France
Actively Recruiting
10
Hopital la Pitie-Salpetriere
Paris, France
Actively Recruiting
11
Knappschaft Krankenhaus Langendreer
Bochum, Germany, 44892
Actively Recruiting
12
Universitaetsklinikum Bonn
Bonn, Germany, 53105
Actively Recruiting
13
Universitaetsklinikum Koeln
Cologne, Germany, 50937
Actively Recruiting
14
Universitaetsklinikum - Essen
Essen, Germany, 45147
Actively Recruiting
15
University Hospital Frankfurt -Senckenberg Institute of Neurooncology
Frankfurt, Germany
Actively Recruiting
16
Universitaetsklinikum Jena
Jena, Germany, 07447
Actively Recruiting
17
Universitaetsklinikum Leipzig-Klinik fuer Strahlentherapie und Radioonkologie
Leipzig, Germany
Actively Recruiting
18
Universitaetsklinikum Regensburg
Regensburg, Germany
Actively Recruiting
19
Diagnostic & Therapeutic Center of Athens Hygeia Hospital S.A.
Athens, Greece
Actively Recruiting
20
Ospedale Bellaria-Bologna
Bologna, Italy
Actively Recruiting
21
Azienda Ospedaliero-Universitaria Careggi
Florence, Italy
Actively Recruiting
22
Istituto Neurologico Carlo Besta
Milan, Italy
Actively Recruiting
23
IRCCS Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
24
Istituto Oncologico Veneto
Padova, Italy
Actively Recruiting
25
IRCCS-Regina Elena National Cancer Center
Roma, Italy, 00144
Actively Recruiting
26
Ospedale San Giovanni - Dipartimento Neuroscienze
Torino, Italy
Actively Recruiting
27
The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis
Amsterdam, Netherlands
Actively Recruiting
28
Leiden University Medical Centre
Leiden, Netherlands
Actively Recruiting
29
Erasmus MC
Rotterdam, Netherlands
Actively Recruiting
30
Oslo University Hospital - Radiumhospitalet
Oslo, Norway
Actively Recruiting
31
Centro Hospitalar Universitario Lisboa Norte - Hospital Sta. Maria
Lisbon, Portugal
Actively Recruiting
32
Instituto Portugues de Oncologia de Lisboa Francisco Gentil - EPE
Lisbon, Portugal
Actively Recruiting
33
Institut Catala d'Oncologia - ICO L'Hospitalet - Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Actively Recruiting
34
Hospital Clinic de Barcelona
Barcelona, Spain
Actively Recruiting
35
Hospital De La Santa Creu I Sant Pau
Barcelona, Spain
Actively Recruiting
36
Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)
Barcelona, Spain
Actively Recruiting
37
Hospital Duran i Reynals
L'Hospitalet de Llobregat, Spain
Actively Recruiting
38
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland
Actively Recruiting
39
UniversitaetsSpital Zurich - Neurology Clinic
Zurich, Switzerland
Actively Recruiting
40
NHS Lothian - The Royal Infirmary Of Edinburgh
Edinburgh, United Kingdom, EH16 4SA
Actively Recruiting
41
Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care
Newcastle upon Tyne, United Kingdom
Actively Recruiting
42
Nottingham University Hospitals NHS Trust - City Hospital
Nottingham, United Kingdom
Actively Recruiting
Research Team
E
EORTC HQ
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
17
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here