Actively Recruiting
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Led by European Organisation for Research and Treatment of Cancer - EORTC · Updated on 2025-12-17
1650
Participants Needed
42
Research Sites
801 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Every new classification depends on its prognostic power and on the type of treatment given. With the rapid evolution of diagnostic methods and the advance in new treatments, there is much less reliable information available on how patients with newly defined brain tumour entities should be treated and what to expect from the current treatments. The goal is to determine whether the new 2021 WHO classification, based on cIMPACT-NOW recommendations, results in more homogeneous patient groups than the old 2016 classification. Furthermore, it will help derive provisional guidelines on how patients with these newly defined tumour entities are best treated. These recommendations will be based on the experience of EORTC investigators with chosen treatments and their experience as reported in this data collection report.
CONDITIONS
Official Title
Observational Study for Assessing Treatment and Outcome of Patients With Primary Brain Tumours Using cIMPACT-NOW and 2021 WHO Classification
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Newly diagnosed or recurrent primary brain tumors within one of the 17 defined cohorts
- Archival tumor tissue from primary tumor available at the study site; tissue from first surgery preferred, but tissue from recurrence surgery allowed except for Cohort 16 where only first surgery tissue is allowed
- Available MRI or CT scans from initial brain tumor diagnosis
- Patient has provided consent for participation
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
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Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 42 locations
1
Innsbruck Universitaetsklinik
Innsbruck, Austria
Actively Recruiting
2
Universitaetsklinikum Wien - AKH unikliniken
Vienna, Austria
Actively Recruiting
3
Onze Lieve Vrouw Ziekenhuis
Aalst, Belgium
Actively Recruiting
4
Institut Jules Bordet
Anderlecht, Belgium
Actively Recruiting
5
Universitair Ziekenhuis Brussel
Brussels, Belgium
Actively Recruiting
6
C.H.U. Sart-Tilman
Liège, Belgium
Actively Recruiting
7
AZ Delta - Campus Rumbeke
Roeselare, Belgium
Actively Recruiting
8
CHU Lyon - Hopital neurologique Pierre Wertheimer
Lyon, France
Actively Recruiting
9
Hopital de La Timone
Marseille, France
Actively Recruiting
10
Hopital la Pitie-Salpetriere
Paris, France
Actively Recruiting
11
Knappschaft Krankenhaus Langendreer
Bochum, Germany, 44892
Actively Recruiting
12
Universitaetsklinikum Bonn
Bonn, Germany, 53105
Actively Recruiting
13
Universitaetsklinikum Koeln
Cologne, Germany, 50937
Actively Recruiting
14
Universitaetsklinikum - Essen
Essen, Germany, 45147
Actively Recruiting
15
University Hospital Frankfurt -Senckenberg Institute of Neurooncology
Frankfurt, Germany
Actively Recruiting
16
Universitaetsklinikum Jena
Jena, Germany, 07447
Actively Recruiting
17
Universitaetsklinikum Leipzig-Klinik fuer Strahlentherapie und Radioonkologie
Leipzig, Germany
Actively Recruiting
18
Universitaetsklinikum Regensburg
Regensburg, Germany
Actively Recruiting
19
Diagnostic & Therapeutic Center of Athens Hygeia Hospital S.A.
Athens, Greece
Actively Recruiting
20
Ospedale Bellaria-Bologna
Bologna, Italy
Actively Recruiting
21
Azienda Ospedaliero-Universitaria Careggi
Florence, Italy
Actively Recruiting
22
Istituto Neurologico Carlo Besta
Milan, Italy
Actively Recruiting
23
IRCCS Ospedale San Raffaele
Milan, Italy, 20132
Actively Recruiting
24
Istituto Oncologico Veneto
Padova, Italy
Actively Recruiting
25
IRCCS-Regina Elena National Cancer Center
Roma, Italy, 00144
Actively Recruiting
26
Ospedale San Giovanni - Dipartimento Neuroscienze
Torino, Italy
Actively Recruiting
27
The Netherlands Cancer Institute-Antoni Van Leeuwenhoekziekenhuis
Amsterdam, Netherlands
Actively Recruiting
28
Leiden University Medical Centre
Leiden, Netherlands
Actively Recruiting
29
Erasmus MC
Rotterdam, Netherlands
Actively Recruiting
30
Oslo University Hospital - Radiumhospitalet
Oslo, Norway
Actively Recruiting
31
Centro Hospitalar Universitario Lisboa Norte - Hospital Sta. Maria
Lisbon, Portugal
Actively Recruiting
32
Instituto Portugues de Oncologia de Lisboa Francisco Gentil - EPE
Lisbon, Portugal
Actively Recruiting
33
Institut Catala d'Oncologia - ICO L'Hospitalet - Hospital Duran i Reynals
L'Hospitalet de Llobregat, Barcelona, Spain, 08908
Actively Recruiting
34
Hospital Clinic de Barcelona
Barcelona, Spain
Actively Recruiting
35
Hospital De La Santa Creu I Sant Pau
Barcelona, Spain
Actively Recruiting
36
Hospital Germans Trias i Pujol (Institut Catala D'Oncologia)
Barcelona, Spain
Actively Recruiting
37
Hospital Duran i Reynals
L'Hospitalet de Llobregat, Spain
Actively Recruiting
38
Centre Hospitalier Universitaire Vaudois
Lausanne, Switzerland
Actively Recruiting
39
UniversitaetsSpital Zurich - Neurology Clinic
Zurich, Switzerland
Actively Recruiting
40
NHS Lothian - The Royal Infirmary Of Edinburgh
Edinburgh, United Kingdom, EH16 4SA
Actively Recruiting
41
Newcastle Hospitals NHS Trust - Freeman Hospital, Northern Centre For Cancer Care
Newcastle upon Tyne, United Kingdom
Actively Recruiting
42
Nottingham University Hospitals NHS Trust - City Hospital
Nottingham, United Kingdom
Actively Recruiting
Research Team
E
EORTC HQ
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
17
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