Actively Recruiting
Observational Study on Energy Expenditure and Protein Metabolism Changes in Patients With Severe Brain Injury.
Led by Southeast University, China · Updated on 2024-08-29
6
Participants Needed
1
Research Sites
87 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Evaluation of early energy metabolism and muscle mass changes in patients with severe brain injury, the impact of nutritional therapy on metabolism and muscle mass, and their relationship with patient prognosis, to provide clinical research references for the implementation of individualized nutritional therapy in patients with severe brain injury.
CONDITIONS
Official Title
Observational Study on Energy Expenditure and Protein Metabolism Changes in Patients With Severe Brain Injury.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients with severe neurological critical illness admitted to the ICU, including moderate to severe acute cerebrovascular disease, severe acute craniocerebral injury and spinal cord injury, central nervous system bacterial infections, status epilepticus, neurosurgical patients requiring life support during the perioperative period, and other progressive severe neurological conditions.
- Age 18 years or older.
- Receiving invasive mechanical ventilation.
- Willing to sign an informed consent form.
You will not qualify if you...
- Women of childbearing age with a positive pregnancy test, pregnant, or lactating women.
- Chronic diseases with severe organ dysfunction or serious complications such as:
- Heart failure classified as New York Heart Association (NYHA) Functional Class IV.
- Chronic respiratory failure that requires long-term oxygen therapy.
- Chronic kidney disease stage 4 or 5.
- History of liver failure, hepatic encephalopathy, or hepatic coma; recent gastrointestinal bleeding due to portal hypertension; or Child-Pugh score of 10 or higher.
- Cancer patients with cachexia or severe organ dysfunction due to tumor effects; recent chemotherapy or immunotherapy within one month.
- Severe immunodeficiency or current use of strong immunosuppressants; agranulocytosis; active blood cancers; HIV stage III; or ongoing immunosuppressive induction therapy.
- Acute gastrointestinal injury grade IV, including intestinal ischemia, necrosis, severe bleeding, or abdominal compartment syndrome needing decompression.
- Implanted life-sustaining devices like pacemakers.
- Critical condition with expected survival less than 24 hours.
- Receiving or requiring dialysis or renal replacement therapy within 6 hours.
- Receiving extracorporeal membrane oxygenation (ECMO) treatment.
- Severe burns covering over 30% of body surface or significant third-degree burns; or burns with severe overall condition, shock, combined injuries, or respiratory tract burns.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Zhongda Hospital, Southeast university
Nanjing, Jiangsu, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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