Observational Study of Adults with Inflammatory Bowel Disease and Nonalcoholic Fatty Liver Disease Multicenter Cohort Research on Clinical Outcomes and Disease Characteristics

What this Trial Is About

Researchers are studying inflammatory bowel diseases IBD, including ulcerative colitis and Crohns disease, which are incurable and increasing in incidence in China. This study focuses on the relationship between IBD and nonalcoholic fatty liver disease NAFLD, also called metabolic dysfunction associated fatty liver disease MASLD, which is a common extraintestinal condition in IBD patients. The research aims to understand how MASLD affects IBD symptoms, treatment outcomes, and prognosis using data from a large patient cohort. This is an observational, multicenter cohort study that collects clinical information and biological samples such as peripheral blood and intestinal mucosa from IBD patients with and without MASLD. The study will analyze clinical characteristics and use statistical methods like logistic regression, COX regression, and Kaplan-Meier survival curves to investigate disease activity and prognosis. No drugs or interventions are administered as part of the study. Participants will be followed for 54 weeks to assess clinical or endoscopic remission as the main outcome. Researchers will monitor disease progression and treatment effects through regular follow-up visits. The study will provide valuable data for improving diagnosis and treatment of IBD patients with MASLD in the region. Total participation time includes the follow-up period and cooperation with clinical evaluations and sample collection.

An Observational Study of Inflammatory Bowel Disease (IBD) Patients With Non-alcoholic Fatty Liver Disease (NAFLD)