Actively Recruiting
An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)
Led by Blueprint Medicines Corporation · Updated on 2026-04-22
150
Participants Needed
1
Research Sites
346 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a Phase 4, non-interventional, observational study to collect detailed data on the clinical characteristics, clinical outcomes and medical management of ISM in real-world settings. The study will describe the demographic and clinical characteristics of ISM participants, including anaphylaxis and bone manifestations in ISM. Quality of life and disease control will be assessed through participant questionnaires. The study will also evaluate real world ISM treatment management, including use of avapritinib.
CONDITIONS
Official Title
An Observational Study in Participants With Indolent Systemic Mastocytosis (ISM)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male or female adults aged 18 years or older with a diagnosis of Indolent Systemic Mastocytosis (ISM) according to World Health Organization criteria
- Currently being treated or planning to be treated with symptom-directed therapies and/or avapritinib for ISM
You will not qualify if you...
- Diagnosis of advanced systemic mastocytosis (AdvSM) or another associated hematologic neoplasm
- Diagnosis of smoldering systemic mastocytosis
- Currently participating in interventional studies in systemic mastocytosis at enrollment
- Receiving treatment with a KIT inhibitor other than avapritinib at enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Brigham and Women's Allergy and Clinical Immunology, Mass General Brigham Healthcare Center (Chestnut Hill)
Chestnut Hill, Massachusetts, United States, 02467
Actively Recruiting
Research Team
B
Blueprint Medicines
CONTACT
B
Blueprint Medicines, EU Contact
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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