Actively Recruiting
An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment
Led by Hoffmann-La Roche · Updated on 2026-04-17
40
Participants Needed
27
Research Sites
78 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This non-interventional study (NIS) is designed to collect information on the effectiveness and safety of treatment received in routine clinical care, as well as measure the health-related quality of life (HRQoL) of participants with Type 3 von Willebrand disease (VWD) receiving prophylactic therapy per local standard of care (SOC) over an observation period of at least 24 weeks.
CONDITIONS
Official Title
An Observational Study of Participants With Type 3 Von Willebrand Disease on Prophylactic Standard-of-Care Treatment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Confirmed diagnosis of Type 3 von Willebrand disease (VWD) based on medical records
- Adequate blood, liver, and kidney function
- Previously used standard prophylactic therapy for VWD 1 to 3 times weekly and plans to continue the same regimen
- For those able to have children: agreement to remain abstinent or use contraception as required
You will not qualify if you...
- Having inherited or acquired bleeding disorders other than Type 3 VWD
- History of gastrointestinal bleeding within 18 months before enrollment or diagnosis of angiodysplasia
- History of intracranial hemorrhage
- Past or current treatment for blood clots or signs of clotting disease
- Other conditions that raise bleeding or clotting risks, such as some autoimmune diseases
- History of serious allergic reactions to monoclonal antibody treatments or emicizumab components
- Use or planned use of systemic immune-modulating drugs (except anti-retroviral therapy) at enrollment
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 27 locations
1
UC Davis
Sacramento, California, United States, 95817
Actively Recruiting
2
University of Florida
Gainesville, Florida, United States, 32610
Actively Recruiting
3
University of Minnesota Medical Center
Minneapolis, Minnesota, United States, 55455
Actively Recruiting
4
Washington University School of Medicine
St Louis, Missouri, United States, 63110
Actively Recruiting
5
UZ Leuven Gasthuisberg
Leuven, Belgium, 3000
Actively Recruiting
6
The Hospital for Sick Children
Toronto, Ontario, Canada, M5G 1X8
Completed
7
McGill University Health Center
Montreal, Quebec, Canada, H4A 3J1
Actively Recruiting
8
IPS SURA Industriales Medellín
Medellín, Colombia
Actively Recruiting
9
Hopital Claude Huriez - CHU Lille
Lille, France, 59037
Actively Recruiting
10
Groupe Hospitalier Necker Enfants Malades
Paris, France, 75015
Actively Recruiting
11
Universitätsklinikum Bonn
Bonn, Germany, 53127
Actively Recruiting
12
Gerinnungszentrum Rhein-Ruhr;Gerinnungsambulanz
Duisburg, Germany, 47051
Actively Recruiting
13
Hämophiliezentrum Med. Klinik III/Institut für Transfusionsmedizin
Frankfurt/M., Germany, 60590
Actively Recruiting
14
Universita' Degli Studi La Sapienza-Ist.Di Ematologia
Rome, Lazio, Italy, 00161
Actively Recruiting
15
IRCCS Ca' Granda Ospedale Maggiore Policlinico
Milan, Lombardy, Italy, 20122
Actively Recruiting
16
AOU Careggi
Florence, Tuscany, Italy, 50134
Actively Recruiting
17
Kurume University Hospital
Fukuoka, Japan, 830-0011
Completed
18
Tokyo Medical University Hospital
Tokyo, Japan, 160-0023
Actively Recruiting
19
Erasmus MC
Rotterdam, Netherlands, 3015 GD
Actively Recruiting
20
Instytut Hematologii i Transfuzjologii
Warsaw, Poland, 02-776
Actively Recruiting
21
Charlotte Maxeke Johannesburg Academic Hospital
Johannesburg, South Africa, 2193
Actively Recruiting
22
Hospital Universitario la Paz
Madrid, Spain, 28046
Actively Recruiting
23
Hospital Universtiario Virgen del Rocio
Seville, Spain, 41013
Actively Recruiting
24
Sahlgrenska Universitetssjukhuset
Gothenburg, Sweden, S-413 45
Actively Recruiting
25
St Thomas' Hospital
London, United Kingdom, SE1 7EH
Actively Recruiting
26
Great Ormond Street Hospital
London, United Kingdom, WC1N 3JH
Actively Recruiting
27
Manchester Royal Infirmary
Manchester, United Kingdom, M13 9WL
Actively Recruiting
Research Team
R
Reference Study ID Number: WP45335 https://forpatients.roche.com/
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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