Actively Recruiting
An Observational Study on Predicting the Efficacy of Immunotherapy for NSCLC Based on LIRAscore
Led by Nanfang Hospital, Southern Medical University · Updated on 2024-01-30
108
Participants Needed
1
Research Sites
149 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a multi-center, observational clinical study to explore the role of LIRAscore in predicting immunotherapy monotherapy and combination with chemotherapy efficacy and prognosis in locally advanced or metastatic non-small-cell lung cancer. The study plans to enroll 108 patients. The primary endpoint of this study was ORR, and secondary endpoints were PFS, OS, DoR, DCR, and safety.
CONDITIONS
Official Title
An Observational Study on Predicting the Efficacy of Immunotherapy for NSCLC Based on LIRAscore
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients voluntarily participated in the study, signed the informed consent, and had good compliance
- Histologically and/or cytologically confirmed previously untreated, locally advanced or metastatic non-small-cell lung cancer (stage IIIB/IIIC or stage IV) without driver gene mutation
- Patients are willing to receive immunotherapy monotherapy or immunotherapy combined with chemotherapy
- The patient agrees to provide the remaining tissue samples after clinical routine diagnosis during the baseline period for LIRA score and PD-L1 immunohistochemical testing
- The Eastern Organization for Oncology (ECOG) physical fitness score is 0 or 1
- The patient has at least one measurable or unmeasurable but evaluable lesion
You will not qualify if you...
- Patients who do not meet the criteria for receiving standard anti-tumor treatment based on clinical routine
- Patients with known EGFR mutations, ALK rearrangements or ROS1 rearrangements
- Patients judged by the researcher as not suitable to participate in this study
AI-Screening
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Trial Site Locations
Total: 1 location
1
Nanfang Hospital, Southern Medical University
Guangzhou, Guangdong, China, 510515
Actively Recruiting
Research Team
W
Wangjun Liao, MD, PhD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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