Actively Recruiting
An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic Cough
Led by Hull University Teaching Hospitals NHS Trust · Updated on 2025-08-01
60
Participants Needed
1
Research Sites
9 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are investigating cough patterns in adults with chronic cough lasting at least 8 weeks. They have developed a new one-page questionnaire that identifies four distinct cough patterns and allows patients to describe other patterns they experience. The questionnaire also measures cough frequency, intensity, and disruption to daily life on a 1-10 scale to calculate an overall severity score. The study aims to understand these cough patterns and how they relate to patient experience. This observational study has two parts. In Part 1, about 30 patients will complete the questionnaire once, providing feedback on its clarity and whether the identified cough patterns cover their experience. In Part 2, another group of 30 patients will complete the questionnaire twice, 2 to 4 weeks apart, to assess how consistent the questionnaire responses are over time. Informed consent and eligibility screening can be done in person or by telephone. Participants will complete the questionnaire describing their cough pattern and rate the frequency, intensity, and life disruption caused by their cough. Researchers will analyze the patterns, severity scores, and the reproducibility of the questionnaire. The study includes eligibility checks, data collection through questionnaires, and monitoring over several weeks. The total involvement depends on the study part but includes initial and follow-up questionnaire completion.
CONDITIONS
Brief Title
An Observational Study Using Novel Questionnaire to Characterize Cough Phenotypes in Patients With Chronic Cough
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Male and female patients over 18 years of age
- Patients with a current cough lasting at least 8 weeks
- Patients with a clear chest X-ray within the previous 2 years
- Non-smokers
- Able to understand and comply with the study requirements and sign informed consent forms
- Good understanding of written and spoken English
You will not qualify if you...
- Recent respiratory tract infection within 4 weeks prior to study
- Current smokers or ex-smokers with less than 6 months' abstinence before the study
- Any clinically significant or unstable medical or psychiatric condition that may interfere with safe participation
- Participation in any clinical research study evaluating an investigational drug or therapy within 30 days or within 5 half-lives of the drug prior to study visit
- Any other reason that the investigator feels the subject should not participate
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person or by telephone)
Duration - 1 day
Participants complete a novel questionnaire to characterize their cough patterns and severity.
1 visit (in-person or remote) for questionnaire completion
Duration - 2 to 4 weeks
Participants complete a follow-up questionnaire 2 to 4 weeks after the initial questionnaire to assess reproducibility and changes in cough severity.
1 follow-up visit or remote questionnaire completion
Trial Site Locations
Total: 1 location
1
Redspiratory Medicine, First Floor, Daisy Building, Castle Hill Hospital
Cottingham, East Yorkshiure, United Kingdom, HU16 5JQ
Actively Recruiting
Research Team
C
Caroline Wright, BSc
R
Rachel Thompson
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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