Study of Viral Biomarkers and microRNAs in Oropharynx and Occult Tumors Positive for Papilloma Virus

What this Trial Is About

This research aims to better understand the role of viral biomarkers, microRNAs, and specific mutation profiles in tumors of the oropharynx and occult tumors positive for human papillomavirus HPV. Researchers want to explore how these markers can improve diagnostic and prognostic accuracy, especially when combined with imaging methods like PET-CT and MRI. The study also seeks to develop organoids and patient-derived xenografts to identify new molecular drugs that might overcome resistance to radiochemotherapy. The study involves collecting tissue, blood, and saliva samples from patients with oropharyngeal squamous cell carcinoma and occult tumors with lymph node metastases. These samples will be analyzed centrally to detect HPV-DNARNA, microRNAs, and mutation profiles. Patients are grouped based on different microRNA expression levels, including a control group. This is an observational study without intervention, focusing on biomarker detection and analysis. Participants will provide biological samples and complete questionnaires during the study. Researchers will monitor the accuracy of biomarker detection at baseline and assess how these markers correlate with disease progression using radiological imaging. The study includes patients aged 18 and older with specific cancer types and performance status allowing participation. The involvement period varies based on clinical follow-up and sample collection schedules.

Observational Study of Viral BIOmarkers and microRNAs in Tumors Orofarynx and Occult Tumors Positive for Papilloma Virus