Actively Recruiting
Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease
Led by Memorial Sloan Kettering Cancer Center · Updated on 2026-04-01
1715
Participants Needed
19
Research Sites
365 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study is being done to find out how often endometrial cancer recurs after the standard treatment as well as how often the standard treatment results in a lymphedema.
CONDITIONS
Official Title
Observational Study of Women With Endometrial Cancer Who Receive the Standard Treatment for Their Disease
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ECOG performance status 0-1 or Karnofsky Performance Status 70%
- Age 18 years or older
- Histologic diagnosis of endometrioid adenocarcinoma on endometrial biopsy or dilatation and curettage
- No signs of extrauterine disease, suspicious pelvic lymph nodes, distant metastases, or cervical invasion on pre-operative imaging and physical exam
- Suitable candidate for surgery
- Planned surgery including hysterectomy, sentinel lymph node biopsy, and bilateral salpingo-oophorectomy
- No history of second primary cancer (invasive or in situ) within past 5 years except non-melanoma skin cancer
- Signed informed consent
- No prior neoadjuvant chemotherapy or radiotherapy for endometrial cancer
- No prior pelvic or abdominal radiotherapy
- Undergo hysterectomy and bilateral salpingo-oophorectomy (unless unilateral already done)
- Bilateral pelvic sentinel lymph node mapping with negative nodes
- Diagnosed with stage I intermediate-risk endometrioid cancer as defined
- Negative pelvic peritoneal cytology
- Adjuvant treatment limited to none or intravaginal radiation only
You will not qualify if you...
- Evidence of extrauterine disease, gross lymph node involvement, or cervical invasion on pre-operative imaging or exam
- Contraindication to sentinel lymph node mapping
- Planned treatment not including surgery or surgery not including hysterectomy with sentinel lymph node biopsy and bilateral salpingo-oophorectomy
- Intra-operative detection of extra-uterine disease or grossly involved lymph nodes
- Any positive pelvic lymph nodes including micrometastasis or isolated tumor cells
- Hysterectomy not performed
- Bilateral salpingo-oophorectomy not performed unless previously done unilaterally
- Failed unilateral or bilateral sentinel lymph node mapping
- Undergoing complete unilateral or bilateral pelvic lymphadenectomy
- Undergoing radical type C hysterectomy
- Stage IA endometrioid cancer grade 1 or 2 with less than 50% myometrial invasion
- Stage IB grade 3 endometrioid cancer
- Non-endometrioid histology including serous, clear cell, carcinosarcoma, undifferentiated, or de-differentiated histology
- Empty sentinel lymph node packets
- Positive peritoneal cytology
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 19 locations
1
Hartford Healthcare Cancer Institute @ Hartford Hospital
Hartford, Connecticut, United States, 06102
Actively Recruiting
2
University of Miami (Data Collection Only)
Miami, Florida, United States, 33136
Not Yet Recruiting
3
Miami Cancer Institute Baptist Health South Florida
Miami, Florida, United States, 33143
Actively Recruiting
4
ADVENTHEALTH (Data collection only)
Orlando, Florida, United States, 32804
Actively Recruiting
5
Mayo Clinic (Data Collection and Data Analysis)
Rochester, Minnesota, United States, 55905
Active, Not Recruiting
6
Memorial Sloan Kettering Basking Ridge (All protocol activities)
Basking Ridge, New Jersey, United States, 07920
Actively Recruiting
7
Memorial Sloan Kettering Monmouth (All protocol activities)
Middletown, New Jersey, United States, 07748
Actively Recruiting
8
Memorial Sloan Kettering Bergen (All protocol activities)
Montvale, New Jersey, United States, 07645
Actively Recruiting
9
Memorial Sloan Kettering Commack (All Protocol Activities)
Commack, New York, United States, 11725
Actively Recruiting
10
Memorial Sloan Kettering Westchester (All protocol activities)
Harrison, New York, United States, 10604
Actively Recruiting
11
Memorial Sloan Kettering Cancer Center
New York, New York, United States, 10065
Actively Recruiting
12
Memorial Sloan Kettering Nassau (All protocol activities)
Rockville Centre, New York, United States, 11553
Actively Recruiting
13
Lehigh Valley Health Network
Allentown, Pennsylvania, United States, 18103
Actively Recruiting
14
Charles University and General University Hospital (Data Collection Only)
Prague, Czechia
Terminated
15
OSPEDALE MICHELE E PIETRO (Data Collection Only)
Ferrera, Italy
Actively Recruiting
16
UNIVERSITY OF MILANO-BICOCCA, ITALY (Data Collection)
Milan, Italy
Not Yet Recruiting
17
FONDAZIONE POLICLINICOUNIVERSITARIO A. GEMELLI, ITALY (Data Collection Only)
Roma, Italy
Not Yet Recruiting
18
L'Azienda Sanitaria Universitaria Friuli Centrale
Udine, Italy
Actively Recruiting
19
OSLO UNIVERSITY HOSPITAL,RIKSHOPITALET (Data Collection Only)
Oslo, Norway
Not Yet Recruiting
Research Team
N
Nadeem Abu-Rustum, MD
CONTACT
M
Mario Leitao, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here