Actively Recruiting
Observing Metabolism of EPA With Consideration of Genetics And Sex
Led by University of Toronto · Updated on 2026-02-27
64
Participants Needed
1
Research Sites
57 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical study is to learn how fast EPA is converted to other molecules, including DHA, with consideration of biological sex and genetics in healthy humans. The main questions it aims to answer are: * How fast is EPA converted to DHA in blood, and is the conversion rate affected by sex and a specific genotype we previously identified? * How do sex and the specific genotypes affect blood DHA levels and other products of DHA in response to dietary EPA? * How fast does dietary EPA replace blood EPA and other omega-3 fatty acids, and is the rate affected by sex and genotype? Participants will be asked to take EPA supplements for 12 weeks and provide a series of venous blood samples over the study duration.
CONDITIONS
Official Title
Observing Metabolism of EPA With Consideration of Genetics And Sex
Who Can Participate
Eligibility Criteria
You may qualify if you...
- BMI between 18.5 and 30 kg/m2
- Healthy adults aged 18 to 35
You will not qualify if you...
- Consumed fish, seafood, or EPA/DHA-enriched foods currently or within the last 6 months
- Taken supplements containing ALA, EPA, or DHA currently or within the last 6 months
- Allergic to fish, gelatin, or any study supplement components
- BMI under 18.5 or over 30 kg/m2
- Women who are pregnant, breastfeeding, or planning pregnancy
- Diagnosed with chronic or communicable diseases
- Taking chronic medications except oral contraceptives
- High blood pressure (above 130/80 mmHg)
- High triglycerides (serum ≥ 1.69 mmol/l)
- High LDL cholesterol (serum LDL-C ≥ 5 mmol/l)
- Expecting lifestyle changes in the next 4 months
- Smoking
- Heavy alcohol consumption (more than 3 drinks per day)
- Major surgery in the past 6 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Clinical Nutrition and Risk Factor Modification Centre
Toronto, Ontario, Canada, M5C 2T2
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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