Actively Recruiting
Obstructive Sleep Apnoea and Difficult Asthma (OSADA)
Led by St. James's Hospital, Ireland · Updated on 2025-09-08
80
Participants Needed
1
Research Sites
30 weeks
Total Duration
On this page
Sponsors
S
St. James's Hospital, Ireland
Lead Sponsor
T
Tallaght University Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma. Participants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group). The primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, and quality of life compared to untreated OSA and to patients without OSA. Secondary outcomes include exacerbation rates, sleep quality, and healthcare utilization. This trial aims to clarify the contribution of OSA to poor asthma control and the potential benefits of integrated sleep and respiratory care in this complex population.
CONDITIONS
Official Title
Obstructive Sleep Apnoea and Difficult Asthma (OSADA)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinical diagnosis of asthma supported by tests showing variable airflow obstruction, bronchial hyper-responsiveness, or eosinophilic inflammation
- Receiving step 4 or step 5 treatment according to The Global Initiative for Asthma (GINA) guidelines
- Age between 18 and 90 years
You will not qualify if you...
- Previous sleep study investigations
- Excessive daytime sleepiness with an Epworth Sleepiness Scale score greater than 17
- Prior diagnosis of any sleep disorder
- Resting low oxygen levels or need for long-term oxygen therapy
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. James's Hospital
Dublin, Dublin, Ireland
Actively Recruiting
Research Team
L
Laura Piggott, BM BS BSc MSc
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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