Intratumor heterogeneity and branched evolution revealed by multiregion sequencing.
Marco Gerlinger, Andrew J Rowan, Stuart Horswell...
https://pubmed.ncbi.nlm.nih.gov/22397650Actively Recruiting
Age: 2Years +
All Genders
ID01915225
Tumor, Normal Tissue and Specimens From Patients Undergoing Evaluation or Surgical Resection of Solid Tumors
Led by National Cancer Institute (NCI) · Updated on 2026-05-29
1800
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying solid tumors in people undergoing surgery or biopsy to collect tissue samples for cancer research. This observational study aims to identify new molecular and biological targets that could help develop future cancer treatments. Participants include adults and children over 2 years old with suspected or confirmed solid tumors, as well as some without tumors undergoing related procedures. Participants will have blood samples taken before their medical procedure. Some may also undergo leukapheresis, a process to collect white blood cells. During surgery or biopsy, samples of tumor tissue and nearby normal tissue will be collected for research. The removed tumor or growth is sent to a lab for analysis. Follow-up visits occur about six weeks after the procedure, and some participants may have additional follow-ups. Throughout the study, researchers will collect biological samples and gather detailed medical and surgical data to help improve cancer treatment research. Participants will have routine checkups after their procedures, and their health will be monitored as part of the study. The main goal is to use these samples and data to find new cancer treatment targets, with participant involvement lasting as long as needed for sample collection and follow-up.
CONDITIONS
Brief Title
Obtaining Solid Tumor Tissue From People Having Biopsy or Surgery for Certain Types of Cancer
Who Can Participate
Age: 2Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Participants must be 2 years of age or older.
- Participants aged 2 to under 18 years may only participate if tissue collection is done during medically necessary surgery and does not add risk.
- Participants must have premalignant, primary, or metastatic solid tumors based on clinical, radiographic, genetic, biochemical, or histological evidence requiring surgery or biopsy.
- Participants without solid tumors undergoing diagnostic, preventative, or therapeutic interventions that generate surgical quality and safety data.
- Laboratory and physical exam results must be within acceptable limits before the planned procedure.
- Participants must be planning to undergo surgery or biopsy as part of their normal treatment.
- Ability to understand and willingness to sign informed consent by participant or guardian.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 screening and enrollment visit
Diagnostic Evaluation
Duration - Day of intervention
Participants undergo diagnostic, preventative, or therapeutic interventions including biopsy or surgery to collect tissue and biologic samples.
1 visit (in-person) during the planned procedure
Long-term Monitoring
Duration - Up to 10 years
Participants are followed to collect detailed history, treatment data, and surgical safety outcomes to help identify novel therapeutic targets.
Follow-up visits as part of routine care
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
C
Cathleen E Hannah, C.R.N.P.
J
Jonathan M Hernandez, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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Dan L Longo
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Shinichi Yachida, Siân Jones, Ivana Bozic...
https://pubmed.ncbi.nlm.nih.gov/20981102Three-Dimensional Imaging of Tumor-Bearing Tissue Using the Iterative Bleaching Extends Multiplexity Approach.
Kirsten Remmert, Yuri Lin, Ashley Rainey...
https://pubmed.ncbi.nlm.nih.gov/40354232