Completed
Amblyopia Treatment Study Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia
Led by Jaeb Center for Health Research · Updated on 2014-03-06
419
Participants Needed
1
Research Sites
613 weeks
Total Duration
On this page
Sponsors
J
Jaeb Center for Health Research
Lead Sponsor
N
National Eye Institute (NEI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
* To determine whether the success rate with drug treatment (atropine) of amblyopia due to strabismus or anisometropia in patients less than 7 years old is equivalent to the success rate with occlusion (patching) therapy * To develop more precise estimates of the success rates of amblyopia treatment * To identify factors that may be associated with successful treatment of amblyopia * To collect data on the course of treated amblyopia to provide more precise estimates of treatment effects than are now available Extended Follow up of Study Patients * Primary: To determine the long-term visual acuity outcome at age 10 years and at age 15 years in patients diagnosed with amblyopia before age 7 years. * Secondary: To determine whether the long-term visual acuity outcome at age 10 years and at age 15 years differs between patients who received patching followed by best clinical care and patients who received atropine followed by best clinical care
CONDITIONS
Brief Title
Occlusion Versus Pharmacologic Therapy for Moderate Amblyopia
Who Can Participate
Eligibility Criteria
Inclusion Criteria:
- Patients must be 7 years old or younger with amblyopia due to strabismus or anisometropia
- Visual acuity in the amblyopic eye must be between 20/40 and 20/100
- Visual acuity in the sound eye or 20/40 or better
- At least 3 lines of acuity difference between the two eyes
Exclusion Criteria:
- More than two months of amblyopia therapy in the past two years
- Myopia (more than -0.50 D)
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