Actively Recruiting
Occurrence of Radiation-induced Otitis Media in Nasopharyngeal Carcinoma Patients After Intensity Modulated Radiotherapy
Led by Sun Yat-sen University · Updated on 2024-08-06
215
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is an observational cohort study to investigate the incidence of radiation-induced otitis media, changes in tubal function and hearing in newly diagnosed nasopharyngeal carcinoma patients without metastasis at multiple time points from baseline to 1 year after radiotherapy.
CONDITIONS
Official Title
Occurrence of Radiation-induced Otitis Media in Nasopharyngeal Carcinoma Patients After Intensity Modulated Radiotherapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 to 70 years, any sex
- ECOG performance status of 0 to 1
- Signed informed consent and understanding of the study
- Newly diagnosed, histologically confirmed non-keratinizing nasopharyngeal carcinoma (WHO type II or III)
- Clinical stage I to IVa based on AJCC 8th edition
- No prior radiotherapy or chemotherapy before enrollment
- Expected survival time of at least 6 months
You will not qualify if you...
- Pregnancy or breastfeeding
- Severe medical conditions affecting heart, liver, lung, kidney, or bone marrow function
- Existing eustachian tube or ear diseases before radiotherapy
- Otitis media present before radiotherapy without improvement by end of radiotherapy
- History of surgery on middle ear, nasal, or nasopharyngeal area on affected side
- Congenital cleft palate or other craniofacial abnormalities
- Histologically confirmed keratinizing nasopharyngeal carcinoma (WHO type I)
- Disease recurrence or distant metastasis
- Prior radiotherapy or chemotherapy
- Age below 18 or above 70 years
- Change in initial treatment due to disease progression during the study
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Nasopharyngeal Carcinoma, Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China, 510060
Actively Recruiting
Research Team
H
Haiqiang Mai, Dr
CONTACT
Q
Qiuyan Chen, Dr
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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