Actively Recruiting
OCD LIFU Target Engagement
Led by University of Pennsylvania · Updated on 2026-04-30
10
Participants Needed
1
Research Sites
10 weeks
Total Duration
On this page
Sponsors
U
University of Pennsylvania
Lead Sponsor
A
Attune Neurosciences Inc
Collaborating Sponsor
AI-Summary
What this Trial Is About
The investigators will conduct a pilot study to evaluate the safety and feasibility of low-intensity focused ultrasound on obsessive-compulsive disorder (OCD) symptoms when delivered to subcortical brain targets. The investigators will use the ATTN201 device to deliver single sessions of unfocused and focused ultrasound to up to three brain targets over 4 study visits and assess the intervention through self-rated scales of OCD symptoms.
CONDITIONS
Official Title
OCD LIFU Target Engagement
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults aged 18 to 60 years old
- Chronic OCD diagnosed by DSM-5 with symptoms for at least 5 years
- Obsessions or compulsions that take more than one hour a day or cause significant distress or impairment
- OCD symptoms not caused by substances or other medical conditions
- Symptoms not better explained by other mental disorders
- Severe OCD symptoms with Y-BOCS I score of 28 or higher within two weeks prior to enrollment
- Compulsions involve hand or arm movements detectable by the study device
- Ability to understand English instructions and comply with study procedures
- Willingness to allow communication between research team and treating clinicians
- Ability and willingness to provide informed consent
You will not qualify if you...
- Unable to undergo MRI due to metal implants, tattoos, claustrophobia, severe anxiety, or inability to remain still
- Unable to fit or wear the ATTN201 device for the entire study
- Hearing loss affecting study compliance or data integrity
- Pregnancy
- Medical conditions or injuries that hinder compliance or affect data integrity
- Previous injury or surgery affecting nerve distribution
- Nerve damage (neuropathy)
- Diagnosed neuromuscular disorder
- Presence of a pacemaker
- History of skin allergies, psoriasis, eczema, dermatitis, or other skin inflammation
- Compulsions that are only mental, verbal, or involve only facial muscles/actions such as blinking or staring
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
Research Team
M
Marshall Nambiar, MS
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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