Actively Recruiting
OCT Angiography and NRAI in Dementia
Led by Oregon Health and Science University · Updated on 2025-09-12
20
Participants Needed
1
Research Sites
480 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary goals of this study are to use optical coherence tomography (OCT) angiography (blood vessel mapping) to: 1. Detect retinal blood vessel and blood flow changes in participants with dementia. 2. Detect amyloid protein deposits in the retinas of participants with dementia.
CONDITIONS
Official Title
OCT Angiography and NRAI in Dementia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Physician-confirmed diagnosis of probable Alzheimer's disease (for dementia subjects)
- Mild dementia defined by Mini-Mental State Exam score of 20 or greater, or Montreal Cognitive Assessment score of 15 or greater, or Clinical Dementia Rating Scale score of 1 (for dementia subjects)
- Age older than 55 years
- Ability to comply with study procedures
- Corrected visual acuity of at least 20/400 in either eye (for dementia subjects)
- Has a legally authorized representative to sign consent and accompany participant (for dementia subjects)
- Able to maintain stable fixation for OCT imaging (for dementia-free controls)
- Corrected visual acuity of at least 20/40 in either eye (for dementia-free controls)
- Dementia-free defined by Mini-Mental Status Exam score of 24 or greater, or Montreal Cognitive Assessment score of 18 or greater, or Clinical Dementia Rating less than 1.0 (for dementia-free controls)
You will not qualify if you...
- Non-Alzheimer's primary neurological diseases affecting the central nervous system (e.g., multiple sclerosis, Parkinson's disease)
- Ocular diseases or pathology within last year that interfere with dementia assessment (e.g., glaucoma, diabetic or hypertensive retinal disease, amblyopia)
- Media opacity such as cataract, corneal scar, or vitreous opacity interfering with retinal imaging
- Previous intraocular surgery except uncomplicated cataract extraction with lens implantation
- Inability to maintain stable fixation for OCT imaging or provide informed consent
- Refractive error greater than +3 or less than -7 diopters, or astigmatism greater than 2 diopters
- Diabetes longer than 10 years or hemoglobin A1C above 10 within 180 days before OCT scan
- Uncontrolled hypertension with systolic BP above 170 or diastolic BP above 100
- Arrhythmia with irregular pulse or heart rate outside 50-110 beats per minute
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Oregon Health & Science University
Portland, Oregon, United States, 97239
Actively Recruiting
Research Team
D
Denzil Romfh, OD
CONTACT
H
Humberto Martinez, COT
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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