Optical Coherence Tomography-Aided Diagnosis and Treatment of Irregular Corneas

What this Trial Is About

Researchers are studying ways to better detect, classify, monitor, and treat irregular corneas caused by conditions such as keratoconus, corneal warpage from contact lenses, dry eye, scars, stromal dystrophies, and other corneal issues. The study aims to improve diagnosis and treatment by using optical coherence tomography (OCT), a detailed imaging technique, to develop systems for classifying corneal irregularities, detecting keratoconus progression, and guiding phototherapeutic keratectomy (PTK) for corneal irregularities. Participants aged 14 to 85 with various corneal irregularities will be included in Group A, whose data will be compared to healthy controls. From Group A, those diagnosed with keratoconus will be followed for up to 4 years to monitor disease progression in Group B. Participants with vision limited by scars, dystrophy, or high astigmatism who may benefit from PTK will be followed for up to 1 year in Group C. OCT will be used to classify irregularities and select participants for these groups. During the study, participants in Group A have one data collection visit, while Groups B and C have follow-up visits lasting up to 4 years and 1 year, respectively. Researchers will use OCT imaging and topography to assess corneal shape and disease progression, as well as guide treatment planning. The study will measure the development of OCT-based metrics for classification, detection of keratoconus progression, and OCT-guided PTK outcomes. Participants' vision and corneal condition will be monitored regularly to evaluate these new diagnostic and treatment methods.

OCT in Diagnosis of Irregular Corneas