Actively Recruiting
OCT in Diagnosis of Irregular Corneas
Led by Oregon Health and Science University · Updated on 2025-09-09
445
Participants Needed
1
Research Sites
669 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This main goal of this study is to improve the detection, classification, monitoring, and treatment of irregular corneas due to keratoconus, warpage, dry eye, scar, stromal dystrophies, and other corneal conditions. The primary goal will be achieved by using optical coherence tomography (OCT) to: 1. Develop an OCT-based system to classify and evaluate corneal-shape irregularities. 2. Develop OCT metrics for more sensitive detection of keratoconus progression. 3. Develop OCT-and-topography guided phototherapeutic keratectomy (PTK) for irregular corneas.
CONDITIONS
Official Title
OCT in Diagnosis of Irregular Corneas
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 14 and 85 years
- Keratoconus with corrected distance visual acuity 20/25 or better in the better eye and keratoconus features in the worse eye
- Contact lens use with corneal topography irregularities
- Dry eye symptoms with Ocular Surface Disease Index score 30 or higher and corneal surface damage
- Epithelial basement membrane dystrophy with corneal opacities and topography irregularities
- Presence of stromal scars, Salzmann's degeneration, stromal dystrophies, or vision issues after LASIK or PRK
- History of radial keratectomy or corneal transplants causing stromal distortion
- Healthy eyes with no previous eye surgeries (normal control group)
- Group B: selected keratoconus participants based on topography
- Group C: selected participants with stromal scarring or distortion who may benefit from phototherapeutic keratectomy (PTK)
You will not qualify if you...
- Unable to give informed consent
- Unable to maintain eye fixation during OCT imaging
- Unable to attend required study visits
- Presence of cataract, retinal disease, glaucoma, or other eye conditions that may affect visual outcomes
- Previous corneal surgeries if considered as keratoconus participant
- Pregnancy or breastfeeding
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Humberto Martinez
Portland, Oregon, United States, 97239
Actively Recruiting
Research Team
H
Humberto Martinez, COT
CONTACT
D
Denny Romfh, OD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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