Ocular Examination with Optical Transmission Tomography (OTT) Compared to OCT and Specular Microscopy for Glaucoma and Other Eye Diseases

What this Trial Is About

Researchers are evaluating a new imaging technology called optical transmission tomography (OTT) that provides high-resolution images of the front parts of the eye. This advanced imaging aims to improve understanding of eye diseases by overcoming the limitations of current clinical imaging systems such as optical coherence tomography (OCT), which have restrictions in resolution, speed, and functional access. The study includes both healthy volunteers and patients with various eye conditions affecting the cornea, ocular surface, lens, or glaucoma. Participants will undergo imaging examinations using three different systems: OTT, OCT, and specular microscopy (SM). For healthy subjects, imaging sessions with each system will be performed twice, at the start and again after two years. For patients, imaging will be done at inclusion and follow-up visits based on their disease assessment schedule, lasting up to four years. Multiple images will be taken by two different operators at different positions during these sessions. During the study, researchers will assess image quality, endothelial cell density, and the ability to visualize new corneal and lens structures over periods ranging from one day to four years. Participants will have multiple imaging sessions and evaluations performed by different operators to ensure detailed data collection. The study will monitor and compare these imaging methods to better understand eye structures and diseases over time.

oCular Examination at Cell RESolution With Optical TransmissionTomography