Actively Recruiting

Age: 18Years - 90Years
All Genders
Healthy Volunteers
ID03835273

Changes in Respiratory Function and Chest Wall Movement Following Oesophagectomy

Led by Imperial College London · Updated on 2025-07-03

100

Participants Needed

1

Research Sites

N/A

Total Duration

On this page

AI-Summary

What this Trial Is About

Researchers are investigating changes in respiratory function and chest wall movement in people who have undergone esophagectomy, a surgery to remove the esophagus, often due to esophageal cancer. The study includes both healthy volunteers and patients who had open esophageal surgery more than one year ago. The goal is to understand how chest wall movement relates to lung capacity and to explore the use of new measurement technologies after surgery. Participants will have chest wall movement measured using a 3D optical motion capture system with small reflective markers and wearable inertial measurement units placed on their chest. Measurements will be taken during various breathing patterns and while using an incentive spirometer, a device that helps assess lung function. The study involves 40 healthy volunteers and 60 patients who had open surgery. Clinical data including lung function tests and health-related quality of life questionnaires will also be collected. Each participant will undergo one assessment session lasting about 60 minutes. During this time, researchers will collect data on chest wall movement, lung function, and quality of life. The study aims to verify the reliability and patient acceptance of the wearable systems, assess differences between surgical approaches, and inform the development of tailored physiotherapy to improve respiratory function. The findings could help optimize recovery for patients after major esophageal surgery.

CONDITIONS

Brief Title

Oesophagectomy and Chest Wall and Respiratory Function

Who Can Participate

Age: 18Years - 90Years
All Genders
Healthy Volunteers

Eligibility Criteria

Eligible

You may qualify if you...

  • Patients treated more than a year ago with open oesophagectomy for oesophageal cancer.
  • Ability to understand and give informed consent.
  • Healthy volunteers with no respiratory disease and no history of upper gastrointestinal surgery.
  • Ability to understand and give informed consent for healthy volunteers.
Not Eligible

You will not qualify if you...

  • Lack of capacity or inability to provide informed consent.
  • Age younger than 18 or older than 90 years.
  • Evidence of cancer recurrence or ongoing postoperative complications more than one year after surgery.
  • Pregnant participants.
  • Inability or exclusion from performing spirometry or respiratory muscle strength testing.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

1
2
3
+1

Your Study Journey

Screening

Duration - 2 to 4 weeks

Participants are screened for eligibility to participate in the trial.

1 visit (in-person)

Diagnostic Evaluation

Duration - Approximately 60 minutes

Participants undergo a one-time assessment measuring chest wall movement using a 3D motion capture system and wearable sensors, lung function tests including incentive spirometry, and complete health-related quality of life questionnaires.

1 visit (in-person)

Long-term Monitoring

Duration - Ongoing after assessment

Data from assessments will be used to evaluate the reliability of measurement systems and to inform future patient-tailored physiotherapy development.

No additional visits required

Trial Site Locations

Total: 1 location

1

Charing Cross Hospital

London, United Kingdom, W6 8RF

Actively Recruiting

Loading map...

Research Team

S

Sheraz R Markar, Dr

K

Karina Tukanova

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

Similar Trials

18F-AraG PET/CT as a Non-Invasive Imaging Biomarker for Chem...

Esophageal Cancer

Actively Recruiting

1 location

A Phase 1/2a Study Utilizing 64Cu-LNTH-1363S (64Cu Radiolabe...

Metastatic Sarcoma

Actively Recruiting

5 locations

A Phase 1/2 Open Label, Dose Escalation and Expansion Study ...

Advanced Solid Tumor

Actively Recruiting

27 locations

Frequently Asked Questions

Have more questions? Get in touch with our team for quick support

Not the Right Trial for You?

Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.

Already have an account? Log in here

Published Research Related To This Trial

Minimally invasive versus open oesophagectomy for patients with oesophageal cancer: a multicentre, open-label, randomised controlled trial.

Surya S A Y Biere, Mark I van Berge Henegouwen, Kirsten W Maas...

https://pubmed.ncbi.nlm.nih.gov/22552194

The impact of combined thoracoscopic and laparoscopic surgery on pulmonary complications after radical esophagectomy in patients with resectable esophageal cancer.

Naoshi Kubo, Masaichi Ohira, Yoshito Yamashita...

https://pubmed.ncbi.nlm.nih.gov/24778050

Accelerated Recovery Within Standardized Recovery Pathways After Esophagectomy: A Prospective Cohort Study Assessing the Effects of Early Discharge on Outcomes, Readmissions, Patient Satisfaction, and Costs.

Henner M Schmidt, Mustapha A El Lakis, Sheraz R Markar...

https://pubmed.ncbi.nlm.nih.gov/27283109

The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology.

N K Aaronson, S Ahmedzai, B Bergman...

https://pubmed.ncbi.nlm.nih.gov/8433390

Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach.

Pernilla Lagergren, Peter Fayers, Thierry Conroy...

https://pubmed.ncbi.nlm.nih.gov/17702567