Actively Recruiting
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
Led by Yale University · Updated on 2026-05-05
600
Participants Needed
6
Research Sites
234 weeks
Total Duration
On this page
Sponsors
Y
Yale University
Lead Sponsor
N
National Institutes of Health (NIH)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this clinical trial is to compare the effectiveness of office-based methadone with pharmacy administration and/or dispensing to office-based buprenorphine for the treatment of opioid use disorder. This study will also examine factors influencing the implementation of office-based methadone.
CONDITIONS
Official Title
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- 18 years of age or older
- Meet Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5) criteria for opioid use disorder
- Initiating a new medication for opioid use disorder treatment episode
You will not qualify if you...
- Prescribed or administered more than 72 hours of medication for opioid use disorder in the 7 days prior to randomization
- Known contraindication to methadone or buprenorphine
- Unwilling to pursue or continue prenatal care or pregnancy counseling if pregnant
- Actively suicidal or severely cognitively impaired preventing informed consent
- Current severe comorbid substance use disorder needing residential or inpatient treatment
- Unable to provide locator information including additional contacts
- Unwilling to follow study procedures or be randomized to treatment
- Previously enrolled in CTN-0131
- Currently enrolled in another conflicting research study
- Currently in jail, prison, or other overnight facility required by court or have pending legal actions preventing participation
- Unable to conduct research assessments in English
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 6 locations
1
Highland Hospital Bridge Clinic at Alameda Health System
Oakland, California, United States, 94602
Actively Recruiting
2
Outpatient Buprenorphine Induction Clinic, University of California, San Francisco
San Francisco, California, United States, 94103
Actively Recruiting
3
Rapid Start Clinic, Kaiser Permanente Colorado
Denver, Colorado, United States, 80205
Actively Recruiting
4
Officed Based Addiction Treatment Program, Boston Medical Center
Boston, Massachusetts, United States, 02118
Actively Recruiting
5
Hennepin Healthcare Addiction Medicine
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
6
Marshall University Division of Addiction Sciences P.R.O.A.C.T
Huntington, West Virginia, United States, 25703
Actively Recruiting
Research Team
J
Jessica Research Associate
CONTACT
M
Melissa Gordon
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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