Oral Glucose Tolerance Test at Home with Continuous Glucose Monitoring Compared to Standard Clinic Testing

What this Trial Is About

Researchers are evaluating a self-administered oral glucose tolerance test (OGTT) at home using continuous glucose monitoring (CGM) compared to a standard clinic-based OGTT in adults with prediabetes. This randomized, crossover study aims to assess the accuracy, feasibility, and diagnostic utility of the home-based test by comparing glucose levels measured by CGM with those from venous plasma glucose in a clinical setting. The study also explores metabolic hormone associations and patient adherence to home testing. Participants will be randomly assigned to complete either the clinic-based OGTT first followed by the home-based OGTT, or vice versa. The home OGTT uses CGM to continuously monitor glucose levels, while the clinic OGTT measures venous plasma glucose. Both tests are performed within a crossover design to allow comparison within each participant. The study includes 75 adults with prediabetes, and the interventions focus on diagnostic testing methods. During the study, participants will undergo both OGTT procedures with glucose monitoring and blood tests to measure plasma glucose. Researchers will evaluate the primary outcome of diagnostic accuracy by comparing the 2-hour CGM glucose reading at home with the 2-hour venous plasma glucose obtained in the clinic. Secondary outcomes include reproducibility of home testing, diagnostic agreement, and hormone relationships. Study participation involves following instructions, using CGM devices, and completing questionnaires, with monitoring of adherence and feasibility throughout the study.

OGTT at Home Using CGM vs at the Clinic