Actively Recruiting
oGVHD After Bone Marrow Transplantation: a Territory-wide Cohort
Led by The University of Hong Kong · Updated on 2021-12-27
500
Participants Needed
1
Research Sites
387 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Allogeneic Haematopoietic stem cell transplantation (HSCT) is an effective treatment for all array of blood or blood-producing organ disorders. Graft-versus-host-disease (GVHD) occurs as a result of an overactive immunological system against normal host tissues. It can happen in the liver, skin, mucosal surface of the eye, gastrointestinal tract, and genitalia. Ocular GVHD occurs in 30-70% of patients after HSCT. It mainly affects the ocular surface, including the conjunctiva and cornea. In severe cases, multiple clinical manifestations can lead to painful non-healing corneal ulcers, secondary infections, and visual loss. oGVHD can be debilitating and severely impact patients' quality of life. However, there are no widely accepted guidelines available for prevention and management. In collaboration with the Department of Haematology of Queen Mary Hospital, the investigators set out to establish a territory-wide cohort of patients receiving HSCT. Primarily, the investigators aim to establish the population-based epidemiology of oGVHD and understand the natural history and the long-term ophthalmic outcomes of oGVHD via this study.
CONDITIONS
Official Title
oGVHD After Bone Marrow Transplantation: a Territory-wide Cohort
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient aged 18 or above
- Underwent allogeneic HSCT in Queen Mary Hospital during the two-year recruitment period
You will not qualify if you...
- Underwent autologous HSCT
- Unable to attend follow-up visits
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong
Hong Kong, Hong Kong
Actively Recruiting
Research Team
A
Allie Lee
CONTACT
A
Alex HS Kan
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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