Actively Recruiting
Olanzapine for Cancer Related Anorexia-cachexia Syndrome
Led by Mahidol University · Updated on 2024-07-24
138
Participants Needed
2
Research Sites
104 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Cancer anorexia-cachexia syndrome is one of the common conditions in cancer patients. Olanzapine has been demonstrated to reduce chemotherapy-induced anorexia. However, there is scarce information regarding olanzapine as a treatment of cancer anorexia among patients who does not receive chemotherapy. Therefore, this randomized controlled trial aims to evaluate the efficacy of olanzapine to lessen cancer cachexia-anorexia syndrome.
CONDITIONS
Official Title
Olanzapine for Cancer Related Anorexia-cachexia Syndrome
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically or cytologically confirmed metastatic or locally advanced cancer
- Anorexia with at least 5% weight loss in the past 6 months or anorexia with a numerical scale score of 5 or higher
- ECOG performance status of 0 to 3
- Ability to complete questionnaires and swallow pills
You will not qualify if you...
- Currently receiving chemotherapy or anti-cancer systemic therapy
- Life expectancy longer than 1 month
- Radiotherapy to head/neck, thoracic, or upper abdomen within the past 2 weeks
- Surgery within the past 4 weeks
- Pregnancy
- Serum bilirubin greater than 2 mg/dl or serum creatinine greater than 2 mg/dl
- Current use of olanzapine or other antipsychotic drugs
- Known cardiac arrhythmia, uncontrolled brain metastasis, history of seizure, or acute coronary event within the past 6 months
AI-Screening
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Trial Site Locations
Total: 2 locations
1
Faculty of Medicine Siriraj Hospital
Bangkok, Thailand, 10260
Actively Recruiting
2
Division of medical oncology, department of medicine Siriraj Hospital
Bangkok, Thailand, 10700
Actively Recruiting
Research Team
S
Suthinee Ithimakin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
3
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