Actively Recruiting
Olanzapine Dose Comparison for the Prevention of HER-INV: A Network Meta-Analysis
Led by Shandong Cancer Hospital and Institute · Updated on 2026-02-11
2000
Participants Needed
1
Research Sites
10 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Olanzapine is an effective antiemetic agent for preventing highly emetogenic regimens-induced nausea and vomiting (HER-INV) in patients receiving highly emetogenic regimens (HER). The optimal dose remains debated, with the standard 10 mg dose often causing significant daytime sedation. Recent evidence suggests that lower doses (2.5 mg and 5 mg) may offer comparable efficacy with improved tolerability. However, no head-to-head randomized controlled trials (RCTs) directly compare all three doses.
CONDITIONS
Official Title
Olanzapine Dose Comparison for the Prevention of HER-INV: A Network Meta-Analysis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Olanzapine was used to prevent nausea and vomiting in adult patients (18 years or older) with solid tumors receiving highly emetogenic chemotherapy
- The study must be a randomized controlled trial (RCT), including conference abstracts if sufficient data are provided
- Olanzapine dose was 2.5 mg, 5 mg, or 10 mg, added to a standard triple antiemetic regimen (NK1 receptor antagonist, 5-HT3 receptor antagonist, and dexamethasone)
- Comparison included any two of the three olanzapine doses or placebo
- At least one pre-specified efficacy or safety outcome was reported
You will not qualify if you...
- Patients with non-solid tumors or pediatric populations
- Non-randomized studies, observational studies, case reports, or reviews
- Studies using olanzapine only as rescue medication
- Studies with overlapping patient populations (only the most recent or complete publication included)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Department of Medical Oncology
Jinan, Shandong, China
Actively Recruiting
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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