Actively Recruiting
Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis
Led by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's · Updated on 2024-12-20
27
Participants Needed
1
Research Sites
228 weeks
Total Duration
On this page
Sponsors
L
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Lead Sponsor
M
Mount Sinai Hospital, Canada
Collaborating Sponsor
AI-Summary
What this Trial Is About
The study aims to investigate the olfactory TDI score (Threshold, Discrimination, Identification) using the Sniffin' sticks test for patients with chronic rhinosinusitis with nasal polyps (CRSwNP) on dupilumab. Twenty-seven adult patients will be followed up during the treatment with dupilumab on three visits to the Otolaryngology Clinic (Baseline, 3 months and 6 months). The primary endpoint will be the TDI score. Nasal polyp score, Quality of Olfactory Disorders - negative symptoms (QOD-NS symptom scores), SNOT-22 will be secondary endpoints.
CONDITIONS
Official Title
Olfactory Outcomes of Dupilumab Treatment for Nasal Polyposis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients older than 18 years old
- Diagnosis of chronic rhinosinusitis with nasal polyps
- Presence of olfactory loss
- Clinical indication for treatment with Dupilumab
You will not qualify if you...
- Olfactory loss caused by sinonasal malignancies
- Olfactory loss caused by trauma
- Idiopathic olfactory loss
- Use of cocaine
- Olfactory loss related to COVID-19
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
St. Joseph's Health Care
London, Ontario, Canada, N5A 4V2
Actively Recruiting
Research Team
C
Cristian Dihel, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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