Actively Recruiting
Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study
Led by Tongji Hospital · Updated on 2025-01-03
80
Participants Needed
1
Research Sites
56 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Identifying the lowest effective opioid dose that achieves rapid pain relief while minimizing side effects is a principal objective in postoperative multimodal analgesia strategies. This study aims to determine the optimal analgesic regimen and dosage by assessing the clinical efficacy of oliceridine for postoperative pain management. It also evaluates oliceridine's contribution to accelerated postoperative recovery, examining aspects such as postoperative pulmonary complications, gastrointestinal function, nausea and vomiting, cognitive function, and emotional distress. Furthermore, the study integrates microbiomics and metabolomics to investigate the underlying molecular mechanisms by which oliceridine promotes rapid postoperative recovery. This research will broaden the clinical data and potential applications of oliceridine, addressing gaps in the field and enhancing practical knowledge. Moreover, this is the first time a clinical study combining multiple omics approaches will provide a comprehensive theoretical foundation for its clinical benefits.
CONDITIONS
Official Title
Oliceridine-Enhanced Analgesia and Recovery: A G-Protein Biased μ-Opioid Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA physical status grades 1 or 2
- Age over 18 years and under 70 years
- Scheduled for laparoscopic upper abdominal surgery under general anesthesia with operation time no more than 4 hours
- Willing to receive postoperative controlled intravenous analgesia
- Able to understand and cooperate with study procedures
- Able to provide and sign written informed consent before study screening
You will not qualify if you...
- Body mass index (BMI) over 30 kg/m2 or under 19 kg/m2
- Preoperative opioid use or presence of acute or chronic pain or increased sensitivity to pain
- History of coronary atherosclerotic heart disease, significant ischemic heart disease, severe angina, heart failure, valvular or other heart diseases
- Severe liver or kidney insufficiency
- History of mental illness or alcoholism
- History of alcohol or drug abuse
- Conditions with increased cranial pressure, intraocular pressure, or glaucoma
- Poorly controlled or untreated hypertension before surgery
- Presence of preeclampsia or eclampsia
- Untreated or undertreated hyperthyroidism
- Presence of autoimmune disease
- Inability to use the numerical rating pain scale
- History of chronic cough
- Expected surgery duration over 4 hours
- Participation in other clinical trials within the last 3 months
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Tongji Hospital
Wuhan, Hubei, China
Actively Recruiting
Research Team
H
Hui Xu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
4
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