Actively Recruiting
Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery
Led by YanYing Xiao · Updated on 2025-07-29
96
Participants Needed
1
Research Sites
27 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of this clinical trial is to evaluate the impact of the analgesic Oliceridine on postoperative nausea and vomiting (PONV) following gynecological laparoscopic surgery. It will also assess the safety profile of Oliceridine. The trial seeks to address the following key questions: Can Oliceridine reduce the incidence of postoperative nausea and vomiting (PONV) in gynecological laparoscopic surgery? Does the incidence of PONV differ between patients receiving Oliceridine and those receiving the commonly used analgesic sufentanil in gynecological laparoscopic surgery? Are there any opioid-related adverse reactions in gynecological laparoscopic surgery patients using Oliceridine? Participants will: Receive Oliceridine or sufentanil for anesthesia induction, maintenance, and postoperative pain management. Vital signs during surgery and the occurrence of postoperative nausea and vomiting will be recorded. Be followed up for at least 48 hours.
CONDITIONS
Official Title
Oliceridine on Postoperative Nausea and Vomiting in Gynecological Laparoscopic Surgery
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Elective gynecological laparoscopic surgery
- Age between 18 and 65 years
- ASA physical status I to III
- Body mass index (BMI) between 18 and 30 kg/m²
You will not qualify if you...
- Severe dysfunction of major organs such as the heart, lungs, or brain
- History of allergy to opioid drugs, propofol, soybeans, or eggs
- Recent use of sedatives, analgesics, or monoamine oxidase inhibitors
- History of alcohol abuse
- Obstructive sleep apnea syndrome
- Difficult airway
- Psychiatric or neurological disorders or communication disorders
- Women who are pregnant or lactating
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Actively Recruiting
Research Team
Y
Yanying Xiao, Doctor
CONTACT
Y
Yaping WANG, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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