Actively Recruiting
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial
Led by Amgen · Updated on 2026-04-16
406
Participants Needed
40
Research Sites
116 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The primary objective of this trial is to evaluate the effect of olpasiran, compared to placebo, on non-calcified plaque (NCP) volume as measured by Coronary Computed Tomography Angiography (CCTA).
CONDITIONS
Official Title
Olpasiran Trials of Cardiovascular Events and Lipoprotein(a) Reduction - Coronary Computed Tomography Angiography Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 35 to 60 80 years
- Lipoprotein(a) level 60 200 nmol/L during screening
- Evidence of coronary artery disease in at least one major epicardial vessel on coronary computed tomography angiography
- History of myocardial infarction (type 1 event due to plaque rupture/erosion) and/or coronary revascularization by percutaneous coronary intervention
You will not qualify if you...
- History of coronary artery bypass graft (CABG)
- Moderate to severe kidney dysfunction
- Elevated liver enzymes (AST or ALT > 3 times upper limit of normal) or total bilirubin > 2 times upper limit of normal
- History of hemorrhagic stroke
- History of major bleeding disorder
- Planned cardiac surgery or arterial revascularization
- Severe heart failure
- Current, recent, or planned lipoprotein apheresis
- Prior treatment with ribonucleic acid therapy targeting lipoprotein(a)
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 40 locations
1
Bridgeport Hospital
Bridgeport, Connecticut, United States, 06610
Actively Recruiting
2
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States, 32216
Actively Recruiting
3
Midwest Heart and Vascular Specialists
Overland Park, Kansas, United States, 66211
Actively Recruiting
4
Flourish Bowie
Bowie, Maryland, United States, 20715
Actively Recruiting
5
Montefiore Medical Center - Bronx
Philadelphia, Pennsylvania, United States, 19141
Actively Recruiting
6
Vital Heart and Vein
Humble, Texas, United States, 77338
Actively Recruiting
7
Advara HeartCare Wesley
Auchenflower, Queensland, Australia, 4066
Actively Recruiting
8
University of The Sunshine Coast Clinical Trials, Sippy Downs
Sippy Downs, Queensland, Australia, 4556
Actively Recruiting
9
Advara HeartCare Leabrook
Leabrook, South Australia, Australia, 5068
Actively Recruiting
10
North York Diagnostic and Cardiac Centre
Vaughan, Ontario, Canada, L6A 4N9
Actively Recruiting
11
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034
Actively Recruiting
12
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, Henan, China, 450052
Actively Recruiting
13
The Second Xiangya Hospital of Central South University
Changsha, Hunan, China, 410011
Actively Recruiting
14
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China, 410013
Actively Recruiting
15
The Second Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China, 210011
Actively Recruiting
16
General Hospital of Ningxia Medical University
Yinchuan, Ningxia, China, 750004
Actively Recruiting
17
Shaanxi Provincial Peoples Hospital
Xi'an, Shaanxi, China, 710068
Actively Recruiting
18
Jinan Central Hospital
Jinan, Shandong, China, 250013
Actively Recruiting
19
Regionshospitalet Gødstrup
Herning, Denmark, 7400
Actively Recruiting
20
Regionshospitalet Viborg
Viborg, Denmark, 8800
Actively Recruiting
21
Centre Hospitalier Universitaire de Nice - Hopital Pasteur
Nice, France, 06000
Actively Recruiting
22
Centre Hospitalier Universitaire de Bordeaux Hopital Haut-Leveque
Pessac, France, 33604
Actively Recruiting
23
Centre Hospitalier Universitaire de Toulouse - Hopital Rangueil
Toulouse, France, 31059
Actively Recruiting
24
Centre Hospitalier Regional Universitaire de Tours - Hopital Trousseau
Tours, France, 37044
Actively Recruiting
25
Charite - Universitaetsmedizin Berlin, Campus Benjamin Franklin
Berlin, Germany, 12203
Actively Recruiting
26
Universitaetsklinikum Essen
Essen, Germany, 45147
Actively Recruiting
27
Universitaetsklinikum Frankfurt
Frankfurt am Main, Germany, 60590
Actively Recruiting
28
Klinikum rechts der Isar der TUM
München, Germany, 80636
Actively Recruiting
29
Azienda Ospedaliera Universitaria di Ferrara Arcispedale Sant Anna
Ferrara, Italy, 44124
Actively Recruiting
30
IRCCS Centro Cardiologico Monzino
Milan, Italy, 20138
Actively Recruiting
31
IRCCS Policlinico San Donato
San Donato Milanese, Italy, 20097
Actively Recruiting
32
Azienda Ospedaliera Ordine Mauriziano di Torino
Torino, Italy, 10128
Actively Recruiting
33
Tomakomai City Hospital
Tomakomai-shi, Hokkaido, Japan, 053-8567
Actively Recruiting
34
Osaka Keisatsu Hospital
Osaka, Osaka, Japan, 543-0042
Actively Recruiting
35
University of Yamanashi Hospital
Chuo-shi, Yamanashi, Japan, 409-3898
Actively Recruiting
36
Tergooiziekenhuizen, locatie Hilversum
Hilversum, Netherlands, 1201 DA
Actively Recruiting
37
Hospital Universitario Virgen Macarena
Seville, Andalusia, Spain, 41009
Actively Recruiting
38
Hospital Alvaro Cunqueiro
Vigo, Galicia, Spain, 36312
Actively Recruiting
39
Hospital Universitari i Politecnic La Fe
Valencia, Valencia, Spain, 46026
Actively Recruiting
40
Hospital Universitario Ramon y Cajal
Madrid, Spain, 28023
Actively Recruiting
Research Team
A
Amgen Call Center
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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