Studying Omega-3 Supplements to Improve Heart Health and Address Dietary Health Differences in Adults Aged 18 to 64

What this Trial Is About

This research aims to understand whether omega-3 fatty acid supplements can lower inflammation-related markers and enhance heart health in healthy adults with different genetic backgrounds. It focuses on whether responses to omega-3 differ based on genetic variation in the FADS gene cluster, specifically rs174537, and whether changes in fatty acid ratios and inflammation markers vary between individuals of African and European ancestry. The study is a randomized, placebo-controlled crossover trial to compare omega-3 supplements and placebo effects across genetic and ancestry groups. Participants receive both omega-3 fatty acid supplements and a safflower oil placebo in two separate 12-week treatment periods, following a randomized crossover design. The order of supplements is randomly assigned, and both participants and investigators are blinded to which supplement is given during each period. The study uses appearance-matched softgels for both supplements to maintain blinding. During the study, participants provide blood samples to analyze fatty acid levels and inflammation markers and complete questionnaires. Researchers will measure changes in circulating arachidonic acid ARA, the ARADGLA ratio, and the ARAEPA ratio between baseline and the end of each treatment period. The trial includes scheduled visits over approximately 32 to 36 weeks, with safety and adherence monitored throughout the study period.

Omega-3D: Omega-3 for Diet-Driven Health Disparities