Comparing Mirabegron and Solifenacin Combination Therapy to Desmopressin Alone for Treating Primary Mono-Symptomatic Nocturnal Enuresis in Children Aged 6 to 18

What this Trial Is About

Researchers are evaluating the safety and effectiveness of combining Solifenacin and Mirabegron compared to Desmopressin in treating children aged 6 to 18 years who have primary mono-symptomatic nocturnal enuresis bedwetting without other urinary symptoms. This condition affects many children and involves involuntary nighttime urination. The study aims to find out if the combination therapy reduces the number of wet nights better than Desmopressin alone and to learn about any medical problems that may occur while taking the treatments. Participants will be randomly assigned to receive either the combination of Solifenacin and Mirabegron or Desmopressin daily for three months. They will visit the clinic once a month for checkups and tests during this period. The treatments involve daily medication taken by mouth, and researchers will track symptoms and side effects over the 90-day treatment period. Throughout the study, participants will keep a diary recording the number of wet nights and any symptoms they experience. Researchers will monitor safety by checking for side effects and will measure the percentage of improvement in wet nights per week after 90 days. The total study duration includes these 3 months of treatment with monthly clinic visits to assess progress and safety.

Omegapres Versus Solifenacin and Mirabegron Combination Therapy in Treatment of Primary MNE