Comparing Omentum Preservation and Complete Omentectomy During Gastrectomy for Resectable Gastric Cancer A Study to See if Preserving the Omentum Affects Three-Year Survival

What this Trial Is About

This research investigates whether preserving the omentum during gastrectomy for gastric cancer is as effective as completely removing it. The study focuses on adult patients with resectable gastric cancer at specific clinical stages, aiming to understand the impact of omentum preservation on three-year overall survival. The trial is a randomized controlled, open, parallel, non-inferiority, multicenter study, exploring an important question about surgery techniques and patient outcomes. Participants will undergo either a gastrectomy with complete removal of the omentum or a gastrectomy that preserves the omentum beyond the gastroepiploic vessels. Both open and minimally invasive subtotal or total gastrectomies are included. Patients are randomly assigned to one of these two surgical approaches, with treatments monitored and compared across multiple centers. During the study, participants will be assessed for overall survival at three years, with additional outcomes measured including operative time, blood loss, complications, lymph node metastases, cancer molecular classification, quality of life, hospital stay, reoperations, and cost-effectiveness. Questionnaires will be completed at various intervals up to 24 months. Clinical and pathological data will be collected post-surgery, and long-term follow-up will assess disease-free survival and survival rates up to five years.

Omentum Preservation Versus Complete Omentectomy in Gastrectomy for Gastric Cancer