Actively Recruiting
Ommaya Reservoir Placement for Brain Tumor Biomarker Access
Led by Mayo Clinic · Updated on 2026-02-13
100
Participants Needed
1
Research Sites
319 weeks
Total Duration
On this page
Sponsors
M
Mayo Clinic
Lead Sponsor
N
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to determine the safety and feasibility of intra-operative Ommaya Reservoir placement during a clinically indicated operation for brain tumor. The Ommaya reservoir will facilitate a longitudinal access to cerebrospinal fluid (CSF) for analysis of potential biomarkers for brain tumor research and individualized monitoring.
CONDITIONS
Official Title
Ommaya Reservoir Placement for Brain Tumor Biomarker Access
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age > 18 years
- Clinical and radiographic evidence suggesting a diagnosis of a brain tumor
- Planned neurosurgical procedure for resection of suspected or previously diagnosed brain tumor as part of routine clinical care
- Willing to undergo neurosurgical resection at Mayo Clinic (Rochester, MN)
- Willingness of the patient or an authorized representative to provide informed consent
- Patient is willing to have their Ommaya sampled on at least 2 future occasions
- Patient is willing to have CSF banked through the neuro-oncology biorepository (requires a separate signature)
You will not qualify if you...
- Vulnerable populations including pregnant women, prisoners, and individuals <18 years old
- Patients not appropriate candidates for surgery due to current or past medical history or uncontrolled concurrent illness
- Prior history of any wound infection
- Any patient the surgeon feels is not an optimal candidate for Ommaya reservoir placement, including factors like surgical anatomy, immunosuppression, or elevated wound infection risk due to diabetes, smoking history, morbid obesity, or other concerns
- Patients with contraindications to lumbar puncture (e.g., large posterior fossa mass at risk of herniation, coagulopathy) will be excluded from the lumbar puncture portion but may still be eligible for Ommaya reservoir placement if other criteria are met
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
E
Essa Sharif
CONTACT
C
Clinical Trials Referral Office
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
BASIC_SCIENCE
Number of Arms
1
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